Bone morphogenetic protein 15

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AliasesBMP15, GDF9B, ODG2, POF4, bone morphogenetic protein 15
External IDsOMIM: 300247 MGI: 1316745 HomoloGene: 3977 GeneCards: BMP15
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for BMP15
Genomic location for BMP15
BandXp11.22Start50,910,784 bp[1]
End50,916,607 bp[1]
RNA expression pattern
PBB GE BMP15 221332 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr X: 50.91 – 50.92 MbChr X: 6.31 – 6.32 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Bone morphogenetic protein 15 is a protein that in humans is encoded by the BMP15 gene.[5][6] It's mainly involved in folliculogenesis.[7]

Structure and expression[edit]

The protein encoded by this gene is a member of the TGF-β superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.[6]


The functions of BMP15 include:[7]

Defects in BMP15 are associated with primary ovarian insufficiency. BMP15may represent a biomarker of ovarian response to ovarian stimulation or oocyte quality.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130385 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023279 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Dube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM (Feb 1999). "The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes". Mol Endocrinol. 12 (12): 1809–17. doi:10.1210/me.12.12.1809. PMID 9849956.
  6. ^ a b "Entrez Gene: BMP15 bone morphogenetic protein 15".
  7. ^ a b c Persani, L.; Rossetti, R.; Di Pasquale, E.; Cacciatore, C.; Fabre, S. (2014). "The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders". Human Reproduction Update. 20 (6): 869–883. doi:10.1093/humupd/dmu036. ISSN 1355-4786. PMID 24980253.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.