BOP reagent

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BOP reagent
BOP reagent.svg
IUPAC name
(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
Other names
Castro's reagent
3D model (JSmol)
ECHA InfoCard 100.054.782
Molar mass 442.287 g/mol
Appearance White crystalline powder
Melting point 136 to 140 °C (277 to 284 °F; 409 to 413 K)
Partially soluble in cold water reacts (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage.

See also[edit]