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BRCA1/BRCA2-containing complex, subunit 3
Symbols BRCC3 ; BRCC36; C6.1A; CXorf53
External IDs OMIM300617 MGI2389572 HomoloGene11530 GeneCards: BRCC3 Gene
EC number
RNA expression pattern
PBB GE BRCC3 216521 s at tn.png
PBB GE BRCC3 221196 x at tn.png
More reference expression data
Species Human Mouse
Entrez 79184 210766
Ensembl ENSG00000185515 ENSMUSG00000031201
UniProt P46736 P46737
RefSeq (mRNA) NM_001018055 NM_001166457
RefSeq (protein) NP_001018065 NP_001159929
Location (UCSC) Chr X:
155.07 – 155.12 Mb
Chr X:
75.42 – 75.45 Mb
PubMed search [1] [2]

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.[1][2][3]


This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.[3]


BRCC3 has been shown to interact with BRE,[2][4] BRCA2,[2] RAD51,[2] BRCA1,[2] P53[2] and BARD1.[2]


  1. ^ Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (Jun 1992). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Human Molecular Genetics 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175. 
  2. ^ a b c d e f g Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569. 
  3. ^ a b "Entrez Gene: BRCC3 BRCA1/BRCA2-containing complex, subunit 3". 
  4. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

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