BRCT domain

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BRCA1 C Terminus (BRCT) domain
PDB 1cdz EBI.jpg
Structure of an XRCC1 BRCT domain.[1]

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,[2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.[3]


Human proteins containing this domain include:


  1. ^ Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi:10.1093/emboj/17.21.6404. PMC 1170965. PMID 9799248.
  2. ^ Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. PMID 9034168.
  3. ^ Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–642. doi:10.1126/science.1088753. PMID 14576433.

External links[edit]

This article incorporates text from the public domain Pfam and InterPro: IPR001357