Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals 
Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.
^Crowley, Thomas E; Kaine Emily M; Yoshida Manabu; Nandi Anindita; Wolgemuth Debra J (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. United States. 16 (8): 1727–37. doi:10.1210/me.2001-0353. ISSN0888-8809. PMID12145330.
Okamoto N, Ando A, Kawai J, et al. (1992). "Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region.". Hum. Immunol. 32 (3): 221–8. doi:10.1016/0198-8859(91)90059-I. PMID1663500.
Denis GV, Green MR (1996). "A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator.". Genes Dev. 10 (3): 261–71. doi:10.1101/gad.10.3.261. PMID8595877.
Thorpe KL, Gorman P, Thomas C, et al. (1997). "Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.". Gene. 200 (1–2): 177–83. doi:10.1016/S0378-1119(97)00415-0. PMID9373153.
Taniguchi Y, Matsuzaka Y, Fujimoto H, et al. (1998). "Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells.". Genomics. 51 (1): 114–23. doi:10.1006/geno.1998.5262. PMID9693039.
Guo N, Faller DV, Denis GV (2000). "Activation-induced nuclear translocation of RING3.". J. Cell. Sci. 113 (17): 3085–91. PMID10934046.
BelAiba RS, Baril P, Chebloune Y, et al. (2001). "Identification and cloning of an 85-kDa protein homologous to RING3 that is upregulated in proliferating endothelial cells.". Eur. J. Biochem. 268 (16): 4398–407. doi:10.1046/j.1432-1327.2001.02355.x. PMID11502199.
Crowley TE, Kaine EM, Yoshida M, et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353. PMID12145330.