BRD2

BRD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X0J, 2DVQ, 2DVR, 2DVS, 2DVV, 2E3K, 2G4A, 2YDW, 2YEK, 3AQA, 3ONI, 4A9E, 4A9F, 4A9H, 4A9I, 4A9J, 4A9M, 4A9N, 4A9O, 4AKN, 4ALG, 4ALH, 4J1P, 4MR5, 4MR6, 4QEU, 4QEV, 4QEW, 4UYF, 4UYG, 4UYH, 5BT5, 5DFD, 5HEM, 5DFB, 5HEL, 5HFQ, 5HEN, 5DFC, 5IG6, 5IBN, 5DW1
Identifiers
Aliases	BRD2, D6S113E, FSH, FSRG1, NAT, RING3, RNF3, O27.1.1, bromodomain containing 2, BRD2-IT1
External IDs	OMIM: 601540; MGI: 99495; HomoloGene: 74540; GeneCards: BRD2; OMA:BRD2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,981,505 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,341,608 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; granulocyte; ; ganglionic eminence; ; left lobe of thyroid gland; ; right testis; ; right lobe of thyroid gland; ; left testis; ; pituitary gland; ; anterior pituitary; ; cerebellar hemisphere;
	Top expressed in
	tail of embryo; ; genital tubercle; ; Rostral migratory stream; ; lacrimal gland; ; internal carotid artery; ; neural layer of retina; ; ventricular zone; ; yolk sac; ; external carotid artery; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding; lysine-acetylated histone binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; nuclear speck;
Biological process	regulation of transcription by RNA polymerase II; nucleosome assembly; regulation of transcription, DNA-templated; transcription, DNA-templated; spermatogenesis; chromatin organization; viral process;
	Sources:Amigo / QuickGO
Orthologs
	6046
	14312
ENSG00000215077; ENSG00000234507; ENSG00000230678; ENSG00000204256; ENSG00000235307;
	ENSG00000236227; ENSG00000234704
	ENSMUSG00000024335
	P25440
	Q7JJ13
	NM_001113182; NM_001199455; NM_001199456; NM_001291986; NM_005104
	NM_001025387; NM_001204973; NM_010238
	NP_001106653; NP_001186384; NP_001186385; NP_001278915; NP_005095
	NP_001191902; NP_034368
	Wikidata
View/Edit Human	View/Edit Mouse

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals ^[5]^[6]^[7]

Template:PBB Summary

Functions

BRD2 has been implicated in cancer.^[5]^[8]
BRD2 loss in mice causes obesity without diabetes for unknown reasons.^[5]
BRD2 may have functional overlap with close homolog BRD3.^[9]
BRD2 function is blocked by BET inhibitors.

Interactions

BRD2 has been shown to interact with E2F2,^[10]^[11] and many transcription factors including GATA1.^[9]

References

^ ^a ^b ^c ENSG00000234507, ENSG00000230678, ENSG00000204256, ENSG00000235307, ENSG00000236227, ENSG00000234704 GRCh38: Ensembl release 89: ENSG00000215077, ENSG00000234507, ENSG00000230678, ENSG00000204256, ENSG00000235307, ENSG00000236227, ENSG00000234704 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024335 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Belkina, A. C.; Denis, G. V. (2012). "BET domain co-regulators in obesity, inflammation and cancer". Nature Reviews Cancer. 12 (7): 465–77. doi:10.1038/nrc3256. PMC 3934568. PMID 22722403.
^ Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S (October 1996). "Phylogeny and structure of the RING3 gene". Immunogenetics. 44 (5): 391–6. doi:10.1007/BF02602785. PMID 8781126.
^ "Entrez Gene: BRD2 bromodomain containing 2".
^ Shi, J; Vakoc, C. R. (2014). "The mechanisms behind the therapeutic activity of BET bromodomain inhibition". Molecular Cell. 54 (5): 728–36. doi:10.1016/j.molcel.2014.05.016. PMC 4236231. PMID 24905006.
^ ^a ^b Stonestrom, A. J.; Hsu, S. C.; Jahn, K. S.; Huang, P; Keller, C. A.; Giardine, B. M.; Kadauke, S; Campbell, A. E.; Evans, P; Hardison, R. C.; Blobel, G. A. (2015). "Functions of BET proteins in erythroid gene expression". Blood. 125: 2825–34. doi:10.1182/blood-2014-10-607309. PMID 25696920.
^ Crowley, Thomas E; Kaine Emily M; Yoshida Manabu; Nandi Anindita; Wolgemuth Debra J (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8). United States: 1727–37. doi:10.1210/me.2001-0353. ISSN 0888-8809. PMID 12145330. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Denis, G V; Vaziri C; Guo N; Faller D V (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8). UNITED STATES: 417–24. ISSN 1044-9523. PMC 3968681. PMID 10965846. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

Functions

Interactions

References

Further reading