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Aliases BRD8, SMAP, SMAP2, p120, bromodomain containing 8
External IDs MGI: 1925906 HomoloGene: 41790 GeneCards: BRD8
RNA expression pattern
PBB GE BRD8 210352 at fs.png

PBB GE BRD8 202227 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 5: 138.14 – 138.18 Mb Chr 18: 34.6 – 34.62 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[3][4][5]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[5]


BRD8 has been shown to interact with Thyroid hormone receptor beta[4] and Retinoid X receptor alpha.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nielsen MS, Petersen CM, Gliemann J, Madsen P (Jun 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochim Biophys Acta. 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617. 
  4. ^ a b Monden T, Wondisford FE, Hollenberg AN (Dec 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J Biol Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056. 
  5. ^ a b "Entrez Gene: BRD8 bromodomain containing 8". 
  6. ^ Monden, T; Kishi M; Hosoya T; Satoh T; Wondisford F E; Hollenberg A N; Yamada M; Mori M (Oct 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. UNITED STATES. 13 (10): 1695–703. doi:10.1210/me.13.10.1695. ISSN 0888-8809. PMID 10517671. 

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