BRD8

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BRD8
Identifiers
Aliases BRD8, SMAP, SMAP2, p120, bromodomain containing 8
External IDs MGI: 1925906 HomoloGene: 41790 GeneCards: BRD8
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for BRD8
Genomic location for BRD8
Band 5q31.2 Start 138,139,766 bp[1]
End 138,178,986 bp[1]
RNA expression pattern
PBB GE BRD8 210352 at fs.png

PBB GE BRD8 202227 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289606
NM_001289607
NM_030147
NM_001361136

RefSeq (protein)

NP_001276535
NP_001276536
NP_084423
NP_001348065

Location (UCSC) Chr 5: 138.14 – 138.18 Mb Chr 18: 34.6 – 34.62 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[5][6][7]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[7]

Interactions[edit]

BRD8 has been shown to interact with Thyroid hormone receptor beta[6] and Retinoid X receptor alpha.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112983 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003778 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nielsen MS, Petersen CM, Gliemann J, Madsen P (Jun 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochim Biophys Acta. 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617. 
  6. ^ a b Monden T, Wondisford FE, Hollenberg AN (Dec 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J Biol Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056. 
  7. ^ a b "Entrez Gene: BRD8 bromodomain containing 8". 
  8. ^ Monden, T; Kishi M; Hosoya T; Satoh T; Wondisford F E; Hollenberg A N; Yamada M; Mori M (Oct 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. UNITED STATES. 13 (10): 1695–703. doi:10.1210/me.13.10.1695. ISSN 0888-8809. PMID 10517671. 

External links[edit]

Further reading[edit]