BRF1 (gene)

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Aliases BRF1, BRF, BRF-1, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF, CFDS, RNA polymerase III transcription initiation factor 90 kDa subunit
External IDs MGI: 1919558 HomoloGene: 1161 GeneCards: BRF1
RNA expression pattern
PBB GE BRF1 215676 at fs.png

PBB GE BRF1 203754 s at fs.png

PBB GE BRF1 215677 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 14: 105.21 – 105.32 Mb Chr 12: 112.96 – 113 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Transcription factor IIIB 90 kDa subunit is a protein that in humans is encoded by the BRF1 gene.[3][4][5]


This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.[5]


BRF1 (gene) has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Wang Z, Roeder RG (August 1995). "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains". Proc Natl Acad Sci U S A. 92 (15): 7026–30. doi:10.1073/pnas.92.15.7026. PMC 41464Freely accessible. PMID 7624363. 
  4. ^ Mital R, Kobayashi R, Hernandez N (January 1997). "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB". Mol Cell Biol. 16 (12): 7031–42. PMC 231706Freely accessible. PMID 8943358. 
  5. ^ a b "Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)". 
  6. ^ a b c Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. 19 (6): 4255–61. doi:10.1128/mcb.19.6.4255. PMC 104385Freely accessible. PMID 10330166. 
  7. ^ Johnston IM, Allison SJ, Morton JP, Schramm L, Scott PH, White RJ (June 2002). "CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells". Mol. Cell. Biol. 22 (11): 3757–68. doi:10.1128/mcb.22.11.3757-3768.2002. PMC 133823Freely accessible. PMID 11997511. 
  8. ^ McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM (August 2000). "Alternatively spliced hBRF variants function at different RNA polymerase III promoters". EMBO J. 19 (15): 4134–43. doi:10.1093/emboj/19.15.4134. PMC 306597Freely accessible. PMID 10921893. 

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