|Chemical and physical data|
|Molar mass||244.267 g/mol|
|3D model (JSmol)|
|(what is this?)|
BRL-50481 is a drug developed by GlaxoSmithKline which is the first compound that acts as a phosphodiesterase inhibitor selective for the PDE7 family. PDE7 activity is encoded by two genes, PDE7A and PDE7B. BRL-50481 actually shows about an 80-fold preference for the PDE7A subtype, for which it was developed, over PDE7B. BRL-50481 has been shown to increase mineralisation activity in osteoblasts, suggesting a potential role for PDE7 inhibitors in the treatment of osteoporosis.
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- Pekkinen, M; Ahlström, ME; Riehle, U; Huttunen, MM; Lamberg-Allardt, CJ (July 2008). "Effects of Phosphodiesterase 7 Inhibition by RNA Interference on the Gene Expression and Differentiation of Human Mesenchymal Stem Cell-Derived Osteoblasts". Bone. 43 (1): 84–91. doi:10.1016/j.bone.2008.02.021. PMID 18420479.