Bromodomain and WD repeat-containing protein 1

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BRWD1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BRWD1, C21orf107, N143, WDR9, DCAF19, bromodomain and WD repeat domain containing 1
External IDs MGI: 1890651 HomoloGene: 23130 GeneCards: BRWD1
RNA expression pattern
PBB GE BRWD1 219280 at fs.png

PBB GE BRWD1 214820 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007246
NM_018963
NM_033656

NM_001103179
NM_145125
NM_176928

RefSeq (protein)

NP_001007247
NP_061836
NP_387505

NP_001096649.1
NP_660107.2
NP_001096649
NP_660107
NP_795902

Location (UCSC) Chr 21: 39.18 – 39.32 Mb Chr 16: 95.99 – 96.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.[3]

Function[edit]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.[3]

References[edit]

External links[edit]

Further reading[edit]