Bromodomain and WD repeat-containing protein 3 is a protein that in humans is encoded by the BRWD3 gene.
The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription.
Mutations in this gene can cause mental retardation or permanent paralysis X-linked type 93, which is also referred to as mental retardation X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.