From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases BYSL, BYSTIN, bystin like
External IDs MGI: 1858419 HomoloGene: 2991 GeneCards: BYSL
RNA expression pattern
PBB GE BYSL 203612 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 41.92 – 41.93 Mb Chr 17: 47.6 – 47.61 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Bystin is a protein that in humans is encoded by the BYSL gene.[3][4][5]


Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.[5]


BYSL has been shown to interact with TROAP.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pack SD, Pak E, Tanigami A, Ledbetter DH, Fukuda MN (Mar 1999). "Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 76–7. doi:10.1159/000015131. PMID 9925933. 
  4. ^ Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D (May 2007). "Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis". Biochem J. 404 (3): 373–81. doi:10.1042/BJ20061597. PMC 1896285Freely accessible. PMID 17381424. 
  5. ^ a b "Entrez Gene: BYSL bystin-like". 
  6. ^ Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN (Apr 1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. doi:10.1073/pnas.95.9.5027. PMC 20207Freely accessible. PMID 9560222. 

External links[edit]

Further reading[edit]