Bacillus clausii

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Bacillus clausii
"B. clausii" from Enterogermina on a glass slide
B. clausii from Enterogermina on a glass slide
Scientific classification edit
Domain: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
B. clausii
Binomial name
Bacillus clausii
Nielsen et al. 1995

Bacillus clausii is a rod-shaped, Gram-positive, motile and spore-forming bacterium that lives in the soil. It is classified as probiotic microorganism that maintains a symbiotic relationship with the host organism.[1] It is currently being studied in respiratory infections[2] and some gastrointestinal disorders.[3] Bacillus clausii, has been found to produce antimicrobial substances that are active against gram positive bacteria including Staphylococcus aureus, Enterococcus faecium, and Clostridium difficile.[1] It is sold by Sanofi as Enterogermina.

Genome structure[edit]

Bacillus clausii has relatively small genome that contains 4.30 Mbp with 4,108 protein coding genes.[1]


  1. ^ a b c Urdaci, MC; Bressollier, P; Pinchuk, I (Jul 2004). "Bacillus clausii probiotic strains: antimicrobial and immunomodulatory activities". Journal of Clinical Gastroenterology. 38 (6 Suppl): S86–90. doi:10.1097/01.mcg.0000128925.06662.69. PMID 15220667.
  2. ^ Marseglia GL, Tosca M, Cirillo I, et al. (March 2007). "Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study". Journal of Therapeutics and Clinical Risk Management. 3 (1): 13–7. doi:10.2147/tcrm.2007.3.1.13. PMC 1936284. PMID 18360611.
  3. ^ Gabrielli M, Lauritano EC, Scarpellini E, et al. (May 2009). "Bacillus clausii as a treatment of small intestinal bacterial overgrowth". The American Journal of Gastroenterology. 104 (5): 1327–8. doi:10.1038/ajg.2009.91. PMID 19352343.

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