Back into Your System spawned its first single, "Always" in late 2002 and reached number 51 on the Billboard Hot 100 and number 1 on the Modern Rock Tracks chart. Its second single was "Rest In Pieces" making several Billboard charts in 2003 and later launching their third single "Raise Up", reaching number 29 on the Mainstream Rock chart.
Back into Your System received mixed reviews from music critics. Brian O'Neill of AllMusic praised the band for making the album more focused in its overall sound and musicianship than Every Six Seconds, concluding that "[The] best thing about Back Into Your System is that the disc doesn't seem to pander to rock radio as much as others of its ilk, but it should still (and did) manage success there regardless." Kaj Roth of Melodic also praised the band's commitment to delving deep into crafting solid musicianship while still retaining a semblance of their given genre. Jon Caramanica of Entertainment Weekly was mixed on Josey Scott's vocal style but felt that "his band’s unsubtle wall of monster metal ensures they never stray too far from bombast." Bob Waliszewski of Plugged In felt the band delivered mixed messages of positivity and hedonism throughout the album's track list, concluding that "With frothing guitars and drooling drums, the guys in Saliva spit out obscenities, spiritual confusion and a smug addiction to celebrity excess. A few good spots, but the parental advisory label is well-deserved."