|Different regions (curvatures) of the vertebral column|
|Classification and external resources|
Back pain is pain felt in the back. Episodes of back pain may be acute, sub-acute, or chronic depending on the duration. The pain may be characterized as a dull ache, shooting or piercing pain, or a burning sensation. The pain may radiate into the arms and hands as well as the legs or feet, and may include paresthesia (tingling with no apparent cause), weakness or numbness in the legs and arms. The anatomic classification of back pain follows the segments of the spine: neck pain (cervical), middle back pain (thoracic), lower back pain (lumbar) or coccydynia (tailbone or sacral pain) with the lumbar vertebrae area most common for pain.
The pain may originate from the muscles, nerves, bones, joints or other structures in the vertebral column (spine). Internal structures such as the gallbladder and pancreas may also cause referred pain in the back.
Back pain is common with about nine out of ten adults experiencing it at some point in their life, and five out of ten working adults having it every year. However, it is rare for it to be permanently disabling, and in most cases of herniated disks and stenosis, rest, injections or surgery have similar general pain resolution outcomes on average after one year. In the United States, acute low back pain is the fifth most common reason for physician visits and causes 40% of missed days off work. Additionally, it is the single leading cause of disability worldwide.
- 1 Classification
- 2 Associated conditions
- 3 Causes
- 4 Diagnosis
- 5 Prevention
- 6 Management
- 7 Pregnancy
- 8 Economics
- 9 Evolutionary perspective
- 10 Research
- 11 References
- 12 External links
Back pain may be classified by various methods to aid its diagnosis and management. The duration of back pain is considered in three categories, following the expected pattern of healing of connective tissue. Acute pain lasts up to 12 weeks, subacute pain refers to the second half of the acute period (6 to 12 weeks), and chronic pain is pain which persists beyond 12 weeks.
Nonspecific back pain is believed to result from soft tissues such as muscles, fascia, and ligaments. Radicular pain with or without spinal stenosis indicates involvement of nervous tissue. Secondary back pain results from a known medical diagnosis such as infection or cancer. Non specific pain indicates that the cause is not known precisely but is believed to be due from the soft tissues such as muscles, fascia, and ligaments.
Back pain has several causes. Approximately 98 percent of back pain patients are diagnosed with nonspecific acute back pain in which no serious underlying pathology is identified. Nearly 2 percent are comprised by metastatic cancers, while serious infections such as spinal osteomyelitis and epidural abscesses account for fewer than 1 percent. The most common cause of neurologic impairment including weakness or numbness results from a herniated disc. Nearly 95 percent of disc herniations occur at the lowest two lumbar intervertebral levels.
Back pain does not usually require immediate medical intervention. The vast majority of episodes of back pain are self-limiting and non-progressive. Most back pain syndromes are due to inflammation, especially in the acute phase, which typically lasts from two weeks to three months.[medical citation needed]
Back pain can be a sign of a serious medical problem, although this is not most frequently the underlying cause:
- Typical warning signs of a potentially life-threatening problem are bowel and/or bladder incontinence or progressive weakness in the legs.
- Severe back pain (such as pain that is bad enough to interrupt sleep) that occurs with other signs of severe illness (e.g. fever, unexplained weight loss) may also indicate a serious underlying medical condition.
- Back pain that occurs after a trauma, such as a car accident or fall, may indicate a bone fracture or other injury.
- Back pain in individuals with medical conditions that put them at high risk for a spinal fracture, such as osteoporosis or multiple myeloma, also warrants prompt medical attention.
- Back pain in individuals with a history of cancer (especially cancers known to spread to the spine like breast, lung and prostate cancer) should be evaluated to rule out metastatic disease of the spine.
A few observational studies suggest that two conditions to which back pain is often attributed, lumbar disc herniation and degenerative disc disease, may not be more prevalent among those in pain than among the general population, and that the mechanisms by which these conditions might cause pain are not known. Other studies suggest that for as many as 85% of cases, no physiological cause can be shown.
A few studies suggest that psychosocial factors such as on-the-job stress and dysfunctional family relationships may correlate more closely with back pain than structural abnormalities revealed in X-rays and other medical imaging scans.
There are several potential sources and causes of back pain. However, the diagnosis of specific tissues of the spine as the cause of pain presents problems. This is because symptoms arising from different spinal tissues can feel very similar and it is difficult to differentiate without the use of invasive diagnostic intervention procedures, such as local anesthetic blocks.
One potential source of back pain is skeletal muscle of the back. Potential causes of pain in muscle tissue include muscle strains (pulled muscles), muscle spasm, and muscle imbalances. However, imaging studies do not support the notion of muscle tissue damage in many back pain cases, and the neurophysiology of muscle spasm and muscle imbalances is not well understood.
Another potential source of lower back pain is the synovial joints of the spine (e.g. zygapophysial joints/facet joints). These have been identified as the primary source of the pain in approximately one third of people with chronic low back pain, and in most people with neck pain following whiplash. However, the cause of zygapophysial joint pain is not fully understood. Capsule tissue damage has been proposed in people with neck pain following whiplash. In people with spinal pain stemming from zygapophysial joints, one theory is that intra-articular tissue such as invaginations of their synovial membranes and fibro-adipose meniscoids (that usually act as a cushion to help the bones move over each other smoothly) may become displaced, pinched or trapped, and consequently give rise to nociception (pain)
There are several common other potential sources and causes of back pain– these include spinal disc herniation and degenerative disc disease or isthmic spondylolisthesis, osteoarthritis (degenerative joint disease) and lumbar spinal stenosis, trauma, cancer, infection, fractures, and inflammatory disease. The anterior ligaments of the intervertebral disc are extremely sensitive, and even the slightest injury can cause significant pain.
New attention has been focused on non-discogenic back pain, where patients have normal or near-normal MRI and CT scans. One of the newer investigations looks into the role of the dorsal ramus in patients that have no radiographic abnormalities (Posterior Rami Syndrome).
Another possible cause of chronic back pain in people with otherwise normal scans is central sensitization, where an initial injury or infection causes a longer-lasting state of heightened sensitivity to pain. This persistent state maintains pain even after the initial injury has healed. Treatment of sensitization typically involves low doses of anti-depressants.
- Smokers are more likely to get back pain than others.
In most cases of low back pain medical consensus advises not seeking an exact diagnosis but instead beginning to treat the pain. This assumes that there is no reason to expect that the person has an underlying problem. In most cases, the pain goes away naturally after a few weeks. Typically, people who do seek diagnosis through imaging are not likely to have a better outcome than those who wait for the condition to resolve.
There is moderate quality evidence that suggests the combination of education and exercise may reduce an individual's risk of developing an episode of low back pain. Lesser quality evidence points to exercise alone as a possible deterrent to the risk of the onset of this condition.
||This section needs more medical references for verification or relies too heavily on primary sources. (January 2016)|
The management goals when treating back pain are to achieve maximal reduction in pain intensity as rapidly as possible, to restore the individual's ability to function in everyday activities, to help the patient cope with residual pain, to assess for side-effects of therapy, and to facilitate the patient's passage through the legal and socioeconomic impediments to recovery. For many, the goal is to keep the pain to a manageable level to progress with rehabilitation, which then can lead to long-term pain relief. Also, for some people the goal is to use non-surgical therapies to manage the pain and avoid major surgery, while for others surgery may be the quickest way to feel better.
Not all treatments work for all conditions or for all individuals with the same condition, and many find that they need to try several treatment options to determine what works best for them. The present stage of the condition (acute or chronic) is also a determining factor in the choice of treatment. Only a minority of back pain patients (most estimates are 1% - 10%) require surgery.
- Heat therapy is useful for back spasms or other conditions. A review concluded that heat therapy can reduce symptoms of acute and sub-acute low-back pain. Some patients find that moist heat works best (e.g. a hot bath or whirlpool) or continuous low-level heat (e.g. a heat wrap that stays warm for 4 to 6 hours).
- Cold compression therapy (e.g. ice or cold pack application) may be effective at relieving back pain in some cases.
- Use of medications in chronic back pain is controversial. The short term use of muscle relaxants is effective in the relief of acute back pain. Opioids have not always been shown to be better than placebo for chronic back pain when the risks and benefits are considered. Non-steroidal anti-inflammatory drugs (NSAIDs/NSAIAs) have been shown to be more effective than placebo, and are usually more effective than paracetamol (acetaminophen). There is insufficient clinical trials to determine if injection therapy, usually with corticosteroids, helps in cases of low back pain.
- "Back school" is an intervention that consists of both education and physical exercises. A 2016 Cochrane review found the evidence concerning back school to be very low quality and was not able to make generalizations as to whether back school is effective or not.
- There is limited evidence that massage may help those with lower back pain. Massage may give short-term pain relief, but not functional improvement, for those with acute lower back pain. Massage may give short-term pain relief and functional improvement for those with long-term (chronic) and sub-acute lower pack pain, but this benefit does not appear to be sustained after 6 months of treatment. There does not appear to be any serious adverse effects associated with massage.
- Exercises can be an effective approach to reducing pain, but should be done under supervision of a licensed health professional. Generally, some form of consistent stretching and exercise is believed to be an essential component of most back treatment programs. However, one study found that exercise is effective for chronic back pain, but not for acute pain. Another study found that back-mobilizing exercises in acute settings are less effective than continuation of ordinary activities as tolerated.
- Education and attitude adjustment to focus on psychological or emotional causes - respondent-cognitive therapy and progressive relaxation therapy can reduce chronic pain.
Surgery may sometimes be appropriate for people with:
- Lumbar disc herniation or degenerative disc disease
- Lumbar spinal stenosis from lumbar disc herniation, degenerative joint disease, or spondylolisthesis
- Compression fracture
Surgery is usually the last resort in the treatment of back pain. It is usually only recommended if all other treatment options have been tried or in an emergency situation. A 2009 systematic review of back surgery studies found that, for certain diagnoses, surgery is moderately better than other common treatments, but the benefits of surgery often decline in the long term.
The main procedures used in back pain surgery are discetomies, spinal fusions, laminectomies, removal of tumors, and vertebroplasties.
There are different types of surgical procedures that are used in treating various conditions causing back pain. Nerve decompression, fusion of body segments and deformity correction surgeries are examples. The first type of surgery is primarily performed in older patients who suffer from conditions causing nerve irritation or nerve damage. Fusion of bony segments is also referred to as a spinal fusion, and it is a procedure used to fuse together two or more bony fragments with the help of metalwork. The latter type of surgery is normally performed to correct congenital deformities or those that were caused by a traumatic fracture. In some cases, correction of deformities involves removing bony fragments or providing stability provision for the spine. Another procedure to repair common intervertebral disc lesions which may offer rapid recovery (just a few days) involves the simple removal of the fibrous nucleus of the affected intervertebral disc. Various techniques, such as in the following paragraph, are described in the literature.
A discectomy is performed when the intervertebral disc have herniated or torn. It involves removing the protruding disc, either a portion of it or all of it, that is placing pressure on the nerve root. The disc material which is putting pressure on the nerve is removed through a small incision that is made over that particular disc. The recovery period after this procedure does not last longer than 6 weeks. The type of procedure in which the bony fragments are removed through an endoscope is called percutaneous disc removal. Microdiscetomies may be performed as a variation of standard discetomies in which a magnifier is used to provide the advantage of a smaller incision, thus a shorter recovery process.
Spinal fusions are performed in cases in which the patient has had the entire disc removed or when another condition has caused the vertebrae to become unstable. The procedure consists in uniting two or more vertebrae by using bone grafts and metalwork to provide more strength for the healing bone. Recovery after spinal fusion may take up to one year, depending greatly on the age of the patient, the reason why surgery has been performed and how many bony segments needed to be fused.
In cases of spinal stenosis and disc herniation, a laminectomy can be performed. During this procedure, pressure on the nerves is reduced, thereby relieving some pain. A specifically designed exercise program during recovery can increase functional status and decrease low back pain as compared to the common recommendation to "stay active".
Back surgery can be performed to prevent the growth of benign and malignant tumors. In the first case, surgery has the goal of relieving the pressure from the nerves which is caused by a benign growth, whereas in the latter the procedure is aimed to prevent the spread of cancer to other areas of the body. Recovery depends on the type of tumor that is being removed, the health status of the patient and the size of the tumor.
- Cold compression therapy is advocated for a strained back or chronic back pain and is postulated to reduce pain and inflammation, especially after strenuous exercise such as golf, gardening, or lifting. However, a meta-analysis of randomized controlled trials by the Cochrane Collaboration concluded "The evidence for the application of cold treatment to low-back pain is even more limited, with only three poor quality studies located. No conclusions can be drawn about the use of cold for low-back pain".
- Bed rest is rarely recommended as it can exacerbate symptoms, and when necessary is usually limited to one or two days. Prolonged bed rest or inactivity is actually counterproductive, as the resulting stiffness leads to more pain.
- Inversion therapy is useful for temporary back relief due to the traction method or spreading of the vertebrae through (in this case) gravity. The patient hangs in an upside down position for a period of time from ankles or knees until this separation occurs. The effect can be achieved without a complete vertical hang (90 degree) and noticeable benefits can be observed at angles as low as 10 to 45 degrees.
- Ultrasound has been shown not to be beneficial and has fallen out of favor.
Chronic back pain
People with back pain lasting for 3 months or more are at risk of physical, psychological and social dysfunctions. Such individuals are likely to experience less pain and disability if they receive a multidisciplinary intervention. This typically involves a combination of physical, psychological and educational interventions delivered by a team of specialists with different skills. Such multidisciplinary treatment programs are often quite intensive and expensive. They are more appropriate for people with severe or complex problems.
People who have chronic back pain may have limited range of motion and/or tenderness upon touch. If the pain continues to worsen, or certain red flags that might indicate a variety of serious conditions are present further testing may be recommended. These red flags include weakness, numbness or tingling, fever, weight loss or problems with bowel and/or bladder control.
- Studies of manipulation suggest that this approach has a benefit similar to other therapies and is superior to placebo.
- Acupuncture has some proven benefit for back painpages however, a recent randomized controlled trial suggested insignificant difference between real and sham acupuncture.
- Electrotherapy, such as a transcutaneous electrical nerve stimulation (TENS) has been proposed. Two randomized controlled trials found conflicting results. This has led the Cochrane Collaboration to conclude that there is inconsistent evidence to support use of TENS. In addition, spinal cord stimulation, where an electrical device is used to interrupt the pain signals being sent to the brain, has been studied for various underlying causes of back pain.[clarification needed]
- It is unclear if low level laser therapy is useful for low back pain.
- A 2017 systematic review found tai chi and mindfulness-based stress reduction are effective interventions.
About 50% of women experience low back pain during pregnancy. Back pain in pregnancy may be severe enough to cause significant pain and disability and pre-dispose patients to back pain in a following pregnancy. No significant increased risk of back pain with pregnancy has been found with respect to maternal weight gain, exercise, work satisfaction, or pregnancy outcome factors such as birth weight, birth length, and Apgar scores.
Biomechanical factors of pregnancy that are shown to be associated with low back pain of pregnancy include abdominal sagittal and transverse diameter and the depth of lumbar lordosis. Typical factors aggravating the back pain of pregnancy include standing, sitting, forward bending, lifting, and walking. Back pain in pregnancy may also be characterized by pain radiating into the thigh and buttocks, night-time pain severe enough to wake the patient, pain that is increased during the night-time, or pain that is increased during the day-time.
The avoidance of high impact, weight-bearing activities and especially those that asymmetrically load the involved structures such as extensive twisting with lifting, may help. Direct bending to the ground without bending the knee causes severe impact on the lower back in pregnancy and in normal individuals, which leads to strain, especially in the lumbo-sacral region that as a result strains the multifidus.
Back pain is regularly cited by national governments as having a major impact on productivity, through loss of workers on sick leave. Some national governments, notably Australia and the United Kingdom, have launched campaigns of public health awareness to help combat the problem, for example the Health and Safety Executive's Better Backs campaign. In the United States lower back pain's economic impact reveals that it is the number one reason for individuals under the age of 45 to limit their activity, second highest complaint seen in physician's offices, fifth most common requirement for hospitalization, and the third leading cause for surgery.
An evolutionary perspective has been used to try to explain why humans have back pain. Selective pressures often resulted in our evolution as a species. At times we are able to postulate the reason for these changes, and other times we cannot seem to arrive at a logical conclusion about the possible benefits of the tradeoff. In the case of back pain, researcher Aaron G. Filler believes the evolutionary changes seen in the human skeleton occurred to ensure the survival of the species. Of special mention here is our ability to walk upright. Walking upright meant that our hands were now free to carry heavy objects and the young across great distances.
- "Paresthesia Definition and Origin". dictionary.com. Retrieved 1 August 2015.
- A.T. Patel, A.A. Ogle. "Diagnosis and Management of Acute Low Back Pain". American Academy of Family Physicians. Retrieved March 12, 2007.
- Manchikanti L, Singh V, Datta S, Cohen SP, Hirsch JA (Jul–Aug 2009). "Comprehensive review of epidemiology, scope, and impact of spinal pain". Pain Physician. 12 (4): E35–70. PMID 19668291.
- Institute for Health Metrics and Evaluation. "2010 Global Burden of Disease Study"
- King W (2013). Encyclopedia of Pain. Springer Reference.
- Mense S, Gerwin RD (2010). Muscle pain: diagnosis and treatment (Online-Ausg. ed.). Heidelberg: Springer. p. 4. ISBN 978-3-642-05467-9.
- Vanwye WR (August 2010). "Nonspecific low back pain: evaluation and treatment tips". The Journal of Family Practice. 59 (8): 445–8. PMID 20714454.
- Slipman, Curtis W.; et al., eds. (2008). Interventional spine : an algorithmic approach. Philadelphia, PA: Saunders Elsevier. p. 13. ISBN 978-0-7216-2872-1.
- "Back Pain". Archived from the original on May 6, 2011. Retrieved June 18, 2010.
- Borenstein DG, O'Mara JW, Boden SD, Lauerman WC, Jacobson A, Platenberg C, Schellinger D, Wiesel SW (September 2001). "The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects : a seven-year follow-up study". The Journal of Bone and Joint Surgery. American Volume. 83–A (9): 1306–11. PMID 11568190.
- Savage RA, Whitehouse GH, Roberts N (1997). "The relationship between the magnetic resonance imaging appearance of the lumbar spine and low back pain, age and occupation in males". European Spine Journal. 6 (2): 106–14. PMC . PMID 9209878. doi:10.1007/BF01358742.
- Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS (July 1994). "Magnetic resonance imaging of the lumbar spine in people without back pain". The New England Journal of Medicine. 331 (2): 69–73. PMID 8208267. doi:10.1056/NEJM199407143310201.
- Kleinstück F, Dvorak J, Mannion AF (September 2006). "Are "structural abnormalities" on magnetic resonance imaging a contraindication to the successful conservative treatment of chronic nonspecific low back pain?". Spine. 31 (19): 2250–7. PMID 16946663. doi:10.1097/01.brs.0000232802.95773.89.
- White AA, Gordon SL (1982). "Synopsis: workshop on idiopathic low-back pain". Spine. 7 (2): 141–9. PMID 6211779. doi:10.1097/00007632-198203000-00009.
- van den Bosch MA, Hollingworth W, Kinmonth AL, Dixon AK (January 2004). "Evidence against the use of lumbar spine radiography for low back pain". Clinical Radiology. 59 (1): 69–76. PMID 14697378. doi:10.1016/j.crad.2003.08.012.
- Burton AK, Tillotson KM, Main CJ, Hollis S (March 1995). "Psychosocial predictors of outcome in acute and subchronic low back trouble". Spine. 20 (6): 722–8. PMID 7604349. doi:10.1097/00007632-199503150-00014.
- Carragee EJ, Alamin TF, Miller JL, Carragee JM (2005). "Discographic, MRI and psychosocial determinants of low back pain disability and remission: a prospective study in subjects with benign persistent back pain". The Spine Journal. 5 (1): 24–35. PMID 15653082. doi:10.1016/j.spinee.2004.05.250.
- Hurwitz EL, Morgenstern H, Yu F (May 2003). "Cross-sectional and longitudinal associations of low-back pain and related disability with psychological distress among patients enrolled in the UCLA Low-Back Pain Study". Journal of Clinical Epidemiology. 56 (5): 463–71. PMID 12812821. doi:10.1016/S0895-4356(03)00010-6.
- Dionne CE (July 2005). "Psychological distress confirmed as predictor of long-term back-related functional limitations in primary care settings". Journal of Clinical Epidemiology. 58 (7): 714–8. PMID 15939223. doi:10.1016/j.jclinepi.2004.12.005.
- Bogduk N (2005). Clinical anatomy of the lumbar spine and sacrum (4th ed.). Edinburgh: Churchill Livingstone. ISBN 0-443-06014-2.
- "Back Pain Information Page: National Institute of Neurological Disorders and Stroke (NINDS)". Ninds.nih.gov. 2010-05-19. Archived from the original on 6 June 2010. Retrieved 2010-06-02.
- Burke GL (2008). "Chapter 5: The Differential Diagnosis of a Nuclear Lesion.". Backache: From Occiput to Coccyx. Vancouver, BC: MacDonald Publishing. ISBN 978-0-920406-47-2.
- Woolf, Clifford J (2011-03-01). "Central sensitization: Implications for the diagnosis and treatment of pain". Pain. 152 (3 Suppl): S2–15. ISSN 0304-3959. PMC . PMID 20961685. doi:10.1016/j.pain.2010.09.030.
- Verdu, Bénédicte; Decosterd, Isabelle; Buclin, Thierry; Stiefel, Friedrich; Berney, Alexandre (2008-01-01). "Antidepressants for the treatment of chronic pain". Drugs. 68 (18): 2611–2632. ISSN 0012-6667. PMID 19093703. doi:10.2165/0003495-200868180-00007.
- Shiri R, Karppinen J, Leino-Arjas P, Solovieva S, Viikari-Juntura E (January 2010). "The association between smoking and low back pain: a meta-analysis". The American Journal of Medicine. 123 (1): 87.e7–35. PMID 20102998. doi:10.1016/j.amjmed.2009.05.028.
- Consumer Reports; American College of Physicians; Annals of Internal Medicine (April 2012), "Imaging tests for lower-back pain: Why you probably don't need them." (PDF), High Value Care, Consumer Reports, retrieved 23 December 2013
- American College of Physicians (September 2013), "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, American College of Physicians, retrieved 10 December 2013
- National Collaborating Centre for Primary Care (May 2009), Low back pain: early management of persistent non-specific low back pain, National Institute for Health and Clinical Excellence, retrieved 9 September 2012
- National Collaborating Centre for Primary Care (January 13, 2011), "ACR Appropriateness Criteria low back pain", Agency for Healthcare Research and Quality, American College of Radiology, retrieved 9 September 2012
- Chou R, Qaseem A, Snow V, Casey D, Cross JT, Shekelle P, Owens DK (October 2007). "Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society". Annals of Internal Medicine. 147 (7): 478–91. PMID 17909209. doi:10.7326/0003-4819-147-7-200710020-00006.
- "Low Back Pain". Occupational medicine practice guidelines : evaluation and management of common health. [S.l.]: Acoem. 2011. ISBN 978-0-615-45228-9.
- Steffens D, Maher CG, Pereira LS, Stevens ML, Oliveira VC, Chapple M, Teixeira-Salmela LF, Hancock MJ (January 2016). "Prevention of Low Back Pain: A Systematic Review and Meta-analysis". JAMA Internal Medicine. 176: 1–10. PMID 26752509. doi:10.1001/jamainternmed.2015.7431.
- Baron, R; Binder, A; Attal, N; Casale, R; Dickenson, AH; Treede, RD (July 2016). "Neuropathic low back pain in clinical practice.". European journal of pain (London, England). 20 (6): 861–73. PMC . PMID 26935254. doi:10.1002/ejp.838.
- French SD, Cameron M, Walker BF, Reggars JW, Esterman AJ (April 2006). "A Cochrane review of superficial heat or cold for low back pain". Spine. 31 (9): 998–1006. PMID 16641776. doi:10.1097/01.brs.0000214881.10814.64.
- van Tulder MW, Touray T, Furlan AD, Solway S, Bouter LM (2003). "Muscle relaxants for non-specific low back pain". The Cochrane Database of Systematic Reviews (2): CD004252. PMID 12804507. doi:10.1002/14651858.CD004252.
- Deshpande A, Furlan AD, Mailis-Gagnon A, Atlas S, Turk D (2007). "Opioids for chronic low-back pain". Cochrane Database of Systematic Reviews (3): CD004959. PMID 17636781. doi:10.1002/14651858.CD004959.pub3.
- Roelofs PD, Deyo RA, Koes BW, Scholten RJ, van Tulder MW (2008). "Non-steroidal anti-inflammatory drugs for low back pain". The Cochrane Database of Systematic Reviews (1): CD000396. PMID 18253976. doi:10.1002/14651858.CD000396.pub3.
- Staal JB, de Bie R, de Vet HC, Hildebrandt J, Nelemans P (2008). "Injection therapy for subacute and chronic low-back pain". The Cochrane Database of Systematic Reviews (3): CD001824. PMID 18646078. doi:10.1002/14651858.CD001824.pub3.
- Poquet, N; Lin, CW; Heymans, MW; van Tulder, MW; Esmail, R; Koes, BW; Maher, CG (26 April 2016). "Back schools for acute and subacute non-specific low-back pain.". The Cochrane database of systematic reviews. 4: CD008325. PMID 27113258. doi:10.1002/14651858.CD008325.pub2.
- Furlan, Andrea D.; Giraldo, Mario; Baskwill, Amanda; Irvin, Emma; Imamura, Marta (2015-09-01). "Massage for low-back pain". The Cochrane Database of Systematic Reviews (9): CD001929. ISSN 1469-493X. PMID 26329399. doi:10.1002/14651858.CD001929.pub3.
- Hayden JA, van Tulder MW, Malmivaara A, Koes BW (2005). "Exercise therapy for treatment of non-specific low back pain". The Cochrane Database of Systematic Reviews (3): CD000335. PMID 16034851. doi:10.1002/14651858.CD000335.pub2.
- Malmivaara A, Häkkinen U, Aro T, Heinrichs ML, Koskenniemi L, Kuosma E, Lappi S, Paloheimo R, Servo C, Vaaranen V (February 1995). "The treatment of acute low back pain—bed rest, exercises, or ordinary activity?". The New England Journal of Medicine. 332 (6): 351–5. PMID 7823996. doi:10.1056/NEJM199502093320602.
- Sarno, John E. (1991). Healing Back Pain: The Mind-Body Connection. Warner Books. ISBN 0-446-39230-8.
- Henschke N, Ostelo RW, van Tulder MW, Vlaeyen JW, Morley S, Assendelft WJ, Main CJ (2010). "Behavioural treatment for chronic low-back pain". The Cochrane Database of Systematic Reviews (7): CD002014. PMID 20614428. doi:10.1002/14651858.CD002014.pub3.
- Levin JH (August 2009). "Prospective, double-blind, randomized placebo-controlled trials in interventional spine: what the highest quality literature tells us". The Spine Journal. 9 (8): 690–703. PMID 18789773. doi:10.1016/j.spinee.2008.06.447.
- Rupert MP, Lee M, Manchikanti L, Datta S, Cohen SP (2009). "Evaluation of sacroiliac joint interventions: a systematic appraisal of the literature". Pain Physician. 12 (2): 399–418. PMID 19305487.
- Chou R, Baisden J, Carragee EJ, Resnick DK, Shaffer WO, Loeser JD (May 2009). "Surgery for low back pain: a review of the evidence for an American Pain Society Clinical Practice Guideline". Spine. 34 (10): 1094–109. PMID 19363455. doi:10.1097/BRS.0b013e3181a105fc.
- Burke, G.L., "Backache from Occiput to Coccyx" Chapter 9
- "Surgery For Back Pain". Retrieved June 18, 2010.
- McGregor, AH; Probyn, K; Cro, S; Doré, CJ; Burton, AK; Balagué, F; Pincus, T; Fairbank, J (9 December 2013). "Rehabilitation following surgery for lumbar spinal stenosis.". The Cochrane database of systematic reviews. 12: CD009644. PMID 24323844. doi:10.1002/14651858.cd009644.pub2.
- Dahm KT, Brurberg KG, Jamtvedt G, Hagen KB (2010). "Advice to rest in bed versus advice to stay active for acute low-back pain and sciatica". The Cochrane Database of Systematic Reviews (6): CD007612. PMID 20556780. doi:10.1002/14651858.CD007612.pub2.
- Hagen KB, Hilde G, Jamtvedt G, Winnem M (2004). "Bed rest for acute low-back pain and sciatica". The Cochrane Database of Systematic Reviews (4): CD001254. PMID 15495012. doi:10.1002/14651858.CD001254.pub2.
- Vidus Vidius. Chirurgia. Cl vi p271. Venice. 1544 (as quoted in the November 1956 issue of the Annals of the Royal College of Surgeons of England Vol 19, pp269-295)
- Robertson VJ, Baker KG (July 2001). "A review of therapeutic ultrasound: effectiveness studies". Physical Therapy. 81 (7): 1339–50. PMID 11444997.
- Kamper SJ, Apeldoorn AT, Chiarotto A, Smeets RJ, Ostelo RW, Guzman J, van Tulder MW (2 September 2014). "Multidisciplinary biopsychosocial rehabilitation for chronic low back pain". The Cochrane Database of Systematic Reviews. The Cochrane Library. 9: CD000963. PMID 25180773. doi:10.1002/14651858.CD000963.pub3.
- Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, van Tulder MW (2011). "Spinal manipulative therapy for chronic low-back pain". The Cochrane Database of Systematic Reviews (2): CD008112. PMID 21328304. doi:10.1002/14651858.CD008112.pub2.
- Assendelft WJ, Morton SC, Yu EI, Suttorp MJ, Shekelle PG (2004). "Spinal manipulative therapy for low back pain". The Cochrane Database of Systematic Reviews (1): CD000447. PMID 14973958. doi:10.1002/14651858.CD000447.pub2.
- Cherkin DC, Sherman KJ, Deyo RA, Shekelle PG (June 2003). "A review of the evidence for the effectiveness, safety, and cost of acupuncture, massage therapy, and spinal manipulation for back pain". Annals of Internal Medicine. 138 (11): 898–906. PMID 12779300. doi:10.7326/0003-4819-138-11-200306030-00011.
- Furlan AD, van Tulder MW, Cherkin DC, Tsukayama H, Lao L, Koes BW, Berman BM (2005). "Acupuncture and dry-needling for low back pain". The Cochrane Database of Systematic Reviews (1): CD001351. PMID 15674876. doi:10.1002/14651858.CD001351.pub2.
- "Interventions pages = –— Low back pain (chronic) - Musculoskeletal disorders pages = –— Clinical Evidence". Clinicalevidence.bmj.com. Retrieved 2010-06-02.
- Cheing GL, Hui-Chan CW (March 1999). "Transcutaneous electrical nerve stimulation: nonparallel antinociceptive effects on chronic clinical pain and acute experimental pain". Archives of Physical Medicine and Rehabilitation. 80 (3): 305–12. PMID 10084439. doi:10.1016/S0003-9993(99)90142-9.
- Deyo RA, Walsh NE, Martin DC, Schoenfeld LS, Ramamurthy S (June 1990). "A controlled trial of transcutaneous electrical nerve stimulation (TENS) and exercise for chronic low back pain". The New England Journal of Medicine. 322 (23): 1627–34. PMID 2140432. doi:10.1056/NEJM199006073222303.
- Khadilkar A, Odebiyi DO, Brosseau L, Wells GA (2008). "Transcutaneous electrical nerve stimulation (TENS) versus placebo for chronic low-back pain". The Cochrane Database of Systematic Reviews (4): CD003008. PMID 18843638. doi:10.1002/14651858.CD003008.pub3.
- Yousefi-Nooraie R, Schonstein E, Heidari K, Rashidian A, Pennick V, Akbari-Kamrani M, Irani S, Shakiba B, Mortaz Hejri SA, Mortaz Hejri SO, Jonaidi A (16 April 2008). "Low level laser therapy for nonspecific low-back pain". The Cochrane Database of Systematic Reviews (2): CD005107. PMID 18425909. doi:10.1002/14651858.CD005107.pub4.
- Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, Fu R, Dana T, Kraegel P, Griffin J, Grusing S, Brodt ED (14 February 2017). "Nonpharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline". Annals of Internal Medicine. 166: 493. PMID 28192793. doi:10.7326/M16-2459.
- Ostgaard HC, Andersson GB, Karlsson K (May 1991). "Prevalence of back pain in pregnancy". Spine. 16 (5): 549–52. PMID 1828912. doi:10.1097/00007632-199105000-00011.
- Katonis, P.; Kampouroglou, A.; Aggelopoulos, A.; Kakavelakis, K.; Lykoudis, S.; Makrigiannakis, A.; Alpantaki, K. (July 1. 2011). "Pregnancy-related low back pain". Hippokratia. 15 (3): 205–210. ISSN 1108-4189. Check date values in:
- "Backache in pregnancy". NHS Choices. Retrieved 2016-05-26.
- Filler AG (2007). "Emergence and optimization of upright posture among hominiform hominoids and the evolutionary pathophysiology of back pain". Neurosurgical Focus. 23 (1): E4. PMID 17961059. doi:10.3171/foc-07/07/e4.
- Yousef, A. A.; Al-deeb, A. E. (March 2013). "A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component". Anaesthesia. 68 (3): 260–266. PMID 23384256. doi:10.1111/anae.12107.
|Wikimedia Commons has media related to Back pain.|
- Back and spine at DMOZ
- Handout on Health: Back Pain at National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Back pain, American Academy of Orthopaedic Surgeons summary
- Qaseem, Amir; Wilt, Timothy J.; McLean, Robert M.; Forciea, Mary Ann (14 February 2017). "Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians". Annals of Internal Medicine. 166: 514–530. PMID 28192789. doi:10.7326/M16-2367.