Bacterial DNA binding protein

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PDB 1p51 EBI.jpg
anabaena hu-dna cocrystal structure (ahu6)
Symbol Bac_DNA_binding
Pfam PF00216
InterPro IPR000119
SCOP 1hue
CDD cd00591

In molecular biology, bacterial DNA binding proteins are a family of small, usually basic proteins of about 90 residues that bind DNA and are known as histone-like proteins.[1][2] Examples include the HU protein in Escherichia coli is a dimer of closely related alpha and beta chains and in other bacteria can be a dimer of identical chains. HU-type proteins have been found in a variety of eubacteria, cyanobacteria and archaebacteria, and are also encoded in the chloroplast genome of some algae.[3] The integration host factor (IHF), a dimer of closely related chains which seem to function in genetic recombination as well as in translational and transcriptional control [4] is found in enterobacteria and viral proteins include the African Swine Fever virus protein A104R (or LMW5-AR).[5]

The exact function of these proteins is not yet clear but they are capable of wrapping DNA and stabilising it from denaturation under extreme environmental conditions. The structure is known for one of these proteins.[6] The protein exists as a dimer and two "beta-arms" function as the non-specific binding site for bacterial DNA.


  1. ^ Drlica K, Rouviere-Yaniv J (September 1987). "Histonelike proteins of bacteria". Microbiol. Rev. 51 (3): 301–19. PMC 373113. PMID 3118156. 
  2. ^ Pettijohn DE (September 1988). "Histone-like proteins and bacterial chromosome structure". J. Biol. Chem. 263 (26): 12793–6. PMID 3047111. 
  3. ^ Wang SL, Liu XQ (December 1991). "The plastid genome of Cryptomonas phi encodes an hsp70-like protein, a histone-like protein, and an acyl carrier protein". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10783–7. doi:10.1073/pnas.88.23.10783. PMC 53015. PMID 1961745. 
  4. ^ Friedman DI (November 1988). "Integration host factor: a protein for all reasons". Cell 55 (4): 545–54. doi:10.1016/0092-8674(88)90213-9. PMID 2972385. 
  5. ^ Neilan JG, Lu Z, Kutish GF, Sussman MD, Roberts PC, Yozawa T, Rock DL (March 1993). "An African swine fever virus gene with similarity to bacterial DNA binding proteins, bacterial integration host factors, and the Bacillus phage SPO1 transcription factor, TF1". Nucleic Acids Res. 21 (6): 1496. doi:10.1093/nar/21.6.1496. PMC 309344. PMID 8464748. 
  6. ^ Tanaka I, Appelt K, Dijk J, White SW, Wilson KS (1984). "3-A resolution structure of a protein with histone-like properties in prokaryotes". Nature 310 (5976): 376–81. doi:10.1038/310376a0. PMID 6540370. 

This article incorporates text from the public domain Pfam and InterPro IPR000119