She is the eldest daughter of The Hon. Siosaia Lausi’i, 7th Ma’afu-’o- Tukui’aulahi, of Vaini.
Tuputupu Vaea and her late husband, Baron Vaea, had seven children and one adopted daughter: Queen Nanasipauʻu Tukuʻaho, 'Alipate Tu'ivanuavou Vaea, 'Amelia Luoluafetu'u Vaea, Luseane Luani (Dowager Lady Luani) and Cassandra Vaea-Tuku'aho (HSH. Princess Tuipelehake). Two sons, Moimoikimofuta Kaifahina Vaea, Ratu Edward Vaea, are deceased.