There are four modes of games available.
- "Exhibition" - One game of baseball. The player can choose two teams from the MLB, one which he/she plays as and one team played by the computer. The player can choose the number of innings in the match as well as other factors.
- "Season" - The player chooses one team and plays one season of baseball within the game controlling that team. The season is supposed to be 2001, and the draw of every team as well as the All-Star Game is matched up exactly with each team's draw during the 2001 season. Also, in season mode, records set in beaseball history for seasons and single games are listed, and if the player's team breaks one, the new record is listed as being set in 2001. If the player's team end up in the top 4, it will go to the playoffs to the World Series.
- Playoffs - The player chooses a team and plays the playoffs to the World Series. The other teams are randomly chosen.
- All-Star Game - The player plays an All-Star Game with the selections from the 2001 team.
All thirty teams from the Major League are available for selection. Only four stadiums (Safeco Field, Wrigley Field, Fenway Park and Pacific Bell Park) are available within the game, and all teams have one of these as their home ground regardless of where they come from. A planned Sega-themed stadium was created but ultimately not included because it did not fit with the game's more serious tone.
All player statistics in Exhibition Mode, Playoffs and the All-Star Game are those of the 2001 season. However, in Season mode, their stats are completely dependent on the results of each game played, meaning that the player has control of them. The game keeps all player statistics, such as batting average, ERA, RBI, season strikeouts and more. The game also has a history of records for seasonal stats and single game stats which the player can break as well.
- "Baseball Advance Nintendo page". Nintendo.com. Archived from the original on 18 May 2007. Retrieved 2007-06-06.
- "Baseball Advance reviews". Metacritic. Archived from the original on 11 May 2007. Retrieved 2007-06-06.
- Team Xbox. "Famitsu XBox Interviews Toshihiro Nagoshi". Archived from the original on 23 March 2012. Retrieved 1 September 2011.