bFGF has been shown in preliminary animal studies to protect the heart from injury associated with a heart attack, reducing tissue death and promoting improved function after reperfusion.
Recent evidence has shown that low levels of FGF2 play a key role in the incidence of excessive anxiety.
Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins. It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems. FGF2, in conjunction with BMP4, promote differentiation of stem cells to mesodermal lineages. After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondrogenic differentiation than untreated stem cells.
^Kim HS (1998). "Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping". Cytogenetics and Cell Genetics83 (1-2): 73. doi:10.1159/000015129. PMID9925931.
^Kühn MC, Willenberg HS, Schott M, Papewalis C, Stumpf U, Flohé S, Scherbaum WA, Schinner S (Feb 2012). "Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation". Molecular and Cellular Endocrinology349 (2): 180–8. doi:10.1016/j.mce.2011.10.018. PMID22040599.
^House SL, Bolte C, Zhou M, Doetschman T, Klevitsky R, Newman G, Schultz Jel J (Dec 2003). "Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia". Circulation108 (25): 3140–8. doi:10.1161/01.CIR.0000105723.91637.1C. PMID14656920.
^Liu Y, Song Z, Zhao Y, Qin H, Cai J, Zhang H, Yu T, Jiang S, Wang G, Ding M, Deng H (Jul 2006). "A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells". Biochemical and Biophysical Research Communications346 (1): 131–9. doi:10.1016/j.bbrc.2006.05.086. PMID16753134.
^Lee TJ, Jang J, Kang S, Jin M, Shin H, Kim DW, Kim BS (Jan 2013). "Enhancement of osteogenic and chondrogenic differentiation of human embryonic stem cells by mesodermal lineage induction with BMP-4 and FGF2 treatment". Biochemical and Biophysical Research Communications430 (2): 793–7. doi:10.1016/j.bbrc.2012.11.067. PMID23206696.
^Shen B, Arese M, Gualandris A, Rifkin DB (Nov 1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochemical and Biophysical Research Communications252 (2): 524–8. doi:10.1006/bbrc.1998.9677. PMID9826564.
^Soulet F, Al Saati T, Roga S, Amalric F, Bouche G (Nov 2001). "Fibroblast growth factor-2 interacts with free ribosomal protein S19". Biochemical and Biophysical Research Communications289 (2): 591–6. doi:10.1006/bbrc.2001.5960. PMID11716516.
Vincent T, Saklatvala J (Jun 2006). "Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?". Biochemical Society Transactions34 (Pt 3): 456–7. doi:10.1042/BST0340456. PMID16709186.
Ribatti D, Vacca A, Rusnati M, Presta M (2007). "The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies". Cytokine & Growth Factor Reviews18 (3-4): 327–34. doi:10.1016/j.cytogfr.2007.04.011. PMID17537668.
Watson R, Anthony F, Pickett M, Lambden P, Masson GM, Thomas EJ (Sep 1992). "Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients". Biochemical and Biophysical Research Communications187 (3): 1227–31. doi:10.1016/0006-291X(92)90434-M. PMID1417798.
Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC (Jan 1991). "Three-dimensional structures of acidic and basic fibroblast growth factors". Science251 (4989): 90–3. doi:10.1126/science.1702556. PMID1702556.
Ago H, Kitagawa Y, Fujishima A, Matsuura Y, Katsube Y (Sep 1991). "Crystal structure of basic fibroblast growth factor at 1.6 A resolution". Journal of Biochemistry110 (3): 360–3. PMID1769963.
Florkiewicz RZ, Shibata F, Barankiewicz T, Baird A, Gonzalez AM, Florkiewicz E, Shah N (1992). "Basic fibroblast growth factor gene expression". Annals of the New York Academy of Sciences638: 109–26. doi:10.1111/j.1749-6632.1991.tb49022.x. PMID1785797.
Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Sep 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". The Journal of Biological Chemistry266 (25): 16778–85. PMID1885605.
Fukushima Y, Byers MG, Fiddes JC, Shows TB (1991). "The human basic fibroblast growth factor gene (FGFB) is assigned to chromosome 4q25". Cytogenetics and Cell Genetics54 (3-4): 159–60. doi:10.1159/000132983. PMID2265560.
Lafage-Pochitaloff M, Galland F, Simonetti J, Prats H, Mattei MG, Birnbaum D (1990). "The human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27". Oncogene Research5 (3): 241–4. PMID2320377.
Story MT, Esch F, Shimasaki S, Sasse J, Jacobs SC, Lawson RK (Feb 1987). "Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue". Biochemical and Biophysical Research Communications142 (3): 702–9. doi:10.1016/0006-291X(87)91471-9. PMID2435284.
Abraham JA, Whang JL, Tumolo A, Mergia A, Fiddes JC (1987). "Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells". Cold Spring Harbor Symposia on Quantitative Biology. 51 Pt 1: 657–68. doi:10.1101/sqb.1986.051.01.078. PMID3472745.
Sommer A, Brewer MT, Thompson RC, Moscatelli D, Presta M, Rifkin DB (Apr 1987). "A form of human basic fibroblast growth factor with an extended amino terminus". Biochemical and Biophysical Research Communications144 (2): 543–50. doi:10.1016/S0006-291X(87)80001-3. PMID3579930.