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Classification and external resources
Specialty hematology
ICD-10 D72.8
ICD-9-CM 288.59

Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.[1]

It has been proposed as an indicator of ovulation.[2]

It is difficult to detect without flow cytometry, because normal levels are so low.[3]

It can be defined as less than 0.01 x 10−9 / L.[4]

Conditions Associated with Decreased Numbers of Blood Basophils

A. Hereditary absence of basophils (very rare)
B. Elevated levels of glucocorticoids
C. Hyperthyroidism or treatment with thyroid hormones
D. Ovulation
E. Hypersensitivity reactions
  1. urticaria [5][6][7]
  2. Anaphylaxis
  3. Drug-induced reactions
F. Leukocytosis (in association with diverse disorders)


  1. ^ "Definition: basophilic leukopenia from Online Medical Dictionary". 
  2. ^ Soni R, Bose S, Gada D, Potnis V (October 1996). "Basopenia as an indicator of ovulation (a short term clinical study)". Indian J. Physiol. Pharmacol. 40 (4): 385–8. PMID 9055113. 
  3. ^ "CLS_3223_Unit 03_WBC". Archived from the original on 2009-01-30. 
  4. ^ "Pathology". 
  5. ^ Lourenço FD, Azor MH, Santos JC (May 2008). "Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus". Br. J. Dermatol. 158 (5): 979–86. doi:10.1111/j.1365-2133.2008.08499.x. PMID 18341658. 
  6. ^ Grattan CE, Dawn G, Gibbs S, Francis DM (March 2003). "Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity". Clin. Exp. Allergy. 33 (3): 337–41. doi:10.1046/j.1365-2222.2003.01589.x. PMID 12614448. 
  7. ^ Grattan CE, Walpole D, Francis DM (December 1997). "Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity". Clin. Exp. Allergy. 27 (12): 1417–24. doi:10.1111/j.1365-2222.1997.tb02986.x. PMID 9433937.