Basophilia

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Basophilia
Classification and external resources
Specialty hematology
ICD-10 D75.8
ICD-9-CM 288.65
DiseasesDB 29698

Basophilia is a condition where the basophil quantity is abnormally elevated (more than 1010 basophils per liter of blood).[1] Basophilia is associated with pruritus (itching) due to the release of histamine.[2]

Causes[edit]

Basophilia as an isolated finding is uncommon. However it is a common feature of myeloproliferative disorders and particularly prominent in chronic myelogenous leukemia.[3][4]

Conditions Associated with Increased Numbers of Blood Basophils

 A. Allergy or inflammation
   1. Ulcerative colitis
   2. Drug, food, inhalant hypersensitivity
   3. Erythroderma, urticaria
   4. Juvenile rheumatoid arthritis
 B. Endocrinopathy
   1. Diabetes mellitus
   2. Estrogen administration
   3. Hypothyroidism (myxedema)
 C. Infection
   1. Chicken pox
   2. Influenza
   3. Smallpox
   4. Tuberculosis
 D. Iron deficiency
 E. Exposure to ionizing radiation
 F. Neoplasia
   1. "Basophilic leukemia" (see text)
 G. Myeloproliferative neoplasms (especially chronic myelogenous leukemia; also polycythemia vera, primary myelofibrosis, essential thrombocythemia)
 H. Carcinoma

References[edit]

  1. ^ "Cytoplasmic basophilia". Veterinary Clinical Pathology Image Database. University of Montreal Veterinary College. Retrieved 2008-09-20. 
  2. ^ Interactive, Wellfire. "Pathology Thread". www.med-ed.virginia.edu. Retrieved 2016-04-07. 
  3. ^ Ravandi, F.; R. Hoffman (2005). "Chapter 17. Phagocytes". In A.V. Hoffbrand; et al. Postgraduate Haematology. Boston: Blackwell Publishing. pp. 296–298. ISBN 1-4051-0821-5. 
  4. ^ Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.  8th edition.