This conflict was an immediate consequence of the Treaty of Amasya signed between the Ottoman and Safavid empires in 1555. This peace deal left a fragmentized Kingdom of Georgia divided into spheres of influence. The kingdoms of Kartli and Kakheti, and the eastern part of the principality of Samtskhe were allotted to the Safavids which had already garrisoned the Georgian capital of Tbilisi.
Luarsab I, the indomitable king of Kartli, refused to recognize the terms of the Amasya treaty and continued to worry Tbilisi. This provoked another Iranian expedition, the fourth in Luarsab’s reign. The Safavid forces, the Qizilbash, placed by ShahTahmasp I under the command of Shāhverdī Khān Ziyādoghlū Qājār, beylerbey of Karabakh, crossed into Kartli in 1556 or 1558. Lursab and his son Svimon met the invaders at Garisi. In a pitched battle, the Georgians managed to beat off the Qizilbash, but Luarsab was killed in action.