Bavituximab

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Bavituximab
Monoclonal antibody
Type Whole antibody
Source Chimeric (mouse/human)
Target phosphatidylserine
Clinical data
Routes of
administration
infusion
ATC code
  • none
Pharmacokinetic data
Biological half-life 30 hrs
Identifiers
CAS Number
ChemSpider
  • none
UNII
Chemical and physical data
Formula C6446H9946N1702O2042S42
Molar mass 145.3 kg/mol
  (verify)

Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell membranes that is exposed when a cell is transformed into solid tumor cancer cell or dies,[1][2] and when cells are infected with hepatitis C.[3] The process of cell death is highly controlled and so there usually no immune response to phosphatidylserine but when bavituximab binds to it, the conjugate appears to stimulate an immune response in humans.[2]

Bavituximab was invented at University of Texas Southwestern Medical Center at Dallas; Peregrine exclusively licensed intellectual property related to bavituximab from the university, including US patent 6,300,308 invented by Alan J. Schroit and US Patents 6,406,693 and 6,312,694 invented in the laboratory Philip E. Thorpe.[4]:6[5]

As of January 2016, bavituximab had been in a Phase III clinical trial for non-small cell lung cancer, a Phase II/III trial for breast cancer, a Phase II trial for pancreatic cancer, a phase I/II trial for hepatocellular carcinoma, and Phase I clinical trials in malignant melanoma and rectal cancer; its development had been discontinued for influenza and prostate cancer.[1] As of 2011 it had been in a Phase II trial for hepatitis C[3] but no results had been reported as of 2016.[1]


References[edit]

  1. ^ a b c Staff, Adis Insight. Bavituximab profile Last updated Jan 27 2016
  2. ^ a b Mahoney K. M.; Rennert P. D.; Freeman, G. J. (August 2015). "Combination cancer immunotherapy and new immunomodulatory targets". Nature Reviews. Drug Discovery. 14 (8): 561–84. PMID 26228759. 
  3. ^ a b Ahn J, Flamm SL. Hepatitis C therapy: other players in the game. Clin Liver Dis. 2011 Aug;15(3):641-56. PMID 21867942
  4. ^ Peregrine's Annual Report for the fiscal year ended April 30, 2015
  5. ^ Peregrine press release: Peregrine Pharmaceuticals Licenses Additional Intellectual Property for Its Anti-Phospholipid Therapy Platform Technology. July 6, 2004