Bayless may refer to:
- Becky Bayless (born 1982), American professional wrestler
- Betsey Bayless, American politician who was the Secretary of State of Arizona from 1997 to 2003
- Charles E. Bayless (born 1942)
- Howard Bayless, American healthcare professional and politician
- Kenny Bayless, professional boxing referee
- Rick Bayless (born 1953), American chef, owner of Frontera Grill in Chicago and star of Mexico: One Plate at a Time
- Rick Bayless (American football) (born 1964), American football player
- Jerryd Bayless (born 1988), American basketball player
- Skip Bayless (born 1951), American television sports commentator for ESPN networks
- Bayless Markets, a supermarket chain
- Bayless School District, a small public school district in urban St. Louis, Missouri, includes Bayless Senior High School
- US v. Bayless, 921 F. Supp. 211 (S.D.N.Y. 1996), a drug seizure case with a controversial evidentiary ruling
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