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Clinical data
Trade namesLotensin, others
License data
Routes of
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding96.7%
MetabolismLiver glucuronidation
Elimination half-life10-11 hours
ExcretionKidney and bile duct
  • 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass424.497 g·mol−1
3D model (JSmol)
  • O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3
  • InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 checkY

Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[2] It is a reasonable initial treatment for high blood pressure.[2] It is taken by mouth.[2] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.[2]

Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.[2] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.[2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.[3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[2]

Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication.[2] In 2021, it was the 147th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[4][5]

Medical uses[edit]

Lotensin is indicated for the treatment of hypertension, to lower blood pressure.[1][2]

Side effects[edit]

The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated.[6]


Benazepril can harm the fetus.[7]

Dosage forms[edit]

It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).

Veterinary uses[edit]

Under the brand names Fortekor (Novartis) and VetACE (Jurox Animal Health),[citation needed] benazepril is used to treat congestive heart failure in dogs[8][9] and chronic kidney failure in cats and dogs.[10]


  1. ^ a b "Lotensin- benazepril hydrochloride tablet". DailyMed. 21 January 2019. Retrieved 11 February 2024.
  2. ^ a b c d e f g h i "Benazepril Hydrochloride Monograph for Professionals". American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  3. ^ "Benazepril Pregnancy and Breastfeeding Warnings". Retrieved 3 March 2019.
  4. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  5. ^ "Benazepril - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  6. ^ Dykewicz MS (April 2004). "Cough and Angioedema From Angiotensin-Converting Enzyme Inhibitors: New Insights Into Mechanisms and Management". Medscape. Retrieved 2 April 2014.
  7. ^ "Lotensin package insert" (PDF). U.S. Food and Drug Administration (FDA). 2011. Retrieved 9 December 2020.
  8. ^ King JN, Mauron C, Kaiser G (December 1995). "Pharmacokinetics of the active metabolite of benazepril, benazeprilat, and inhibition of plasma angiotensin-converting enzyme activity after single and repeated administrations to dogs". American Journal of Veterinary Research. 56 (12): 1620–1628. PMID 8599524.
  9. ^ O'Grady MR, O'Sullivan ML, Minors SL, Horne R (2009). "Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers". Journal of Veterinary Internal Medicine. 23 (5): 977–983. doi:10.1111/j.1939-1676.2009.0346.x. PMID 19572914.
  10. ^ "Fortekor Flavor Tabs (5 mg) (Canada) for Animal Use". Retrieved 9 December 2020.