Bendroflumethiazide

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Bendroflumethiazide
Bendroflumethiazide.svg
Bendroflumethiazide-3D-vdW.png
Systematic (IUPAC) name
3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com Consumer Drug Information
Pregnancy
category
Legal status
Routes of
administration
Oral
Pharmacokinetic data
Bioavailability 100%
Protein binding 96%
Metabolism extensive
Biological half-life 3-4 hours[2]
Identifiers
CAS Registry Number 73-48-3 YesY
ATC code C03AA01
PubChem CID: 2315
IUPHAR/BPS 7122
DrugBank DB00436 YesY
ChemSpider 2225 YesY
UNII 5Q52X6ICJI YesY
KEGG D00650 YesY
ChEBI CHEBI:3013 YesY
ChEMBL CHEMBL1684 YesY
Chemical data
Formula C15H14F3N3O4S2
Molecular mass 421.415 g/mol
 YesY (what is this?)  (verify)

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.

Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Adverse effects[edit]

Common adverse effects:[3]

Rare adverse effects:[4]

Alcohol[edit]

Bendroflumethiazide is known to have an adverse interaction with alcohol. It is advised that those using this diuretic should abstain from alcohol consumption during use, as it is possible to experience a sudden drop in blood pressure, especially if standing up.

Other considerations[edit]

Bendroflumethiazide should not be used by pregnant women, or women who have just given birth. Due to the nature of the medication, it is possible for it to pass into the breast milk and consequently to the child. It is also known that bendroflumethiazide suppresses the production of breast milk. Pregnant or lactating women with hypertension may need to discuss with their prescriber as to which alternative treatment may be more suitable. Bendroflumethiazide may also impair the user's motor skills, therefore it is important to be aware of its effects and to take caution when operating machinery of driving.[5]

References[edit]

  1. ^ BNF 45 March 2003
  2. ^ Ed. Sean C. Sweetman (ed.). Martindale: The complete drug reference (33 ed.). Pharmaceutical Press. 
  3. ^ Bendroflumethiazide Side Effects - Common euroClinix.co.uk
  4. ^ Bendroflumethiazide Side Effects Drugs.com
  5. ^ Bendroflumethiazide (Bendroflumethiazide 2.5mg tablets) NHS.uk