Benidipine

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Benidipine
Skeletal formula of benidipine
Ball-and-stick model of the benidipine molecule
Systematic (IUPAC) name
O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
Identifiers
CAS Number 105979-17-7 YesY
ATC code C08CA15 (WHO)
PubChem CID 656668
ChemSpider 571013 N
UNII 4G9T91JS7E YesY
ChEMBL CHEMBL2218858 N
Chemical data
Formula C28H31N3O6
Molar mass 505.562
 NYesY (what is this?)  (verify)

Benidipine (INN), also known as Benidipinum or benidipine hydrochloride, is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). It is a triple L-, T-, and N-type calcium channel blocker. It is reno- and cardioprotective.

Dosing[edit]

Benidipine is dosed as 2–4 mg once daily.[1]

Availability[edit]

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.

Benidipine is only licensed for use in Japan and selected Southeast Asian countries, where it is sold as 4 mg tablets.

Mechanism[edit]

Benidipine is a calcium channel blocker.

Benidipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid.[2]

References[edit]

  1. ^ Hi-Eisai Pharmaceutical, Inc. "Coniel (benidipine) package insert (Philippines)". MIMS Philippines. CMPMedica. Retrieved 2008-03-31. 
  2. ^ Luther, James M. (2014). "Is there a new dawn for selective mineralocorticoid receptor antagonism?". Current Opinion in Nephrology and Hypertension. 23 (5): 456–461. doi:10.1097/MNH.0000000000000051. ISSN 1062-4821.