Oxybuprocaine

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Oxybuprocaine
Oxybuprocaine.svg
Clinical data
Trade names Novesin(e)
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • AU: D
Routes of
administration
Topical
ATC code
Pharmacokinetic data
Metabolism Esterases in blood plasma and liver
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C17H28N2O3
Molar mass 308.41 g/mol
3D model (Jmol)
  (verify)

Oxybuprocaine (INN), also known as benoxinate or BNX, is an ester-type local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.

Safety for use in pregnancy and lactation has not been established.

Uses[edit]

Pharmacokinetics[edit]

Anaesthesia starts with a latency of 30 to 50 seconds and lasts for about 10 to 30 minutes, depending on perfusion. The drug is metabolised by esterases in blood plasma and liver.[2]

Adverse effects[edit]

When used excessively, oxybuprocaine like any other topical anesthetic used in the eye and on mucous membranes (like for example tetracaine, proxymetacaine and proparacaine) can cause irritation, hypersensitivity, anaphylaxis, irreversible corneal damage and even complete destruction of the cornea.[1][3] (Excessive use means several times a day during several days or even weeks.)

Interactions[edit]

Oxybuprocaine is incompatible with silver and mercury salts, as well as basic substances. It also reduces the antimicrobial action of sulfonamides.[2]

See also[edit]

References[edit]

  1. ^ a b Drugs.com: Minims Oxybuprocaine Hydrochloride 0.4%
  2. ^ a b c d e Jasek, W, ed. (2007). Austria-Codex (in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4. 
  3. ^ McGee, H. T.; Fraunfelder, F. W. (2007). "Toxicities of topical ophthalmic anesthetics". Expert Opinion on Drug Safety. 6 (6): 637–640. doi:10.1517/14740338.6.6.637. PMID 17967152.