From Wikipedia, the free encyclopedia
Jump to: navigation, search
Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Legal status
  • OTC(UK)
Routes of
Oral, topical
Pharmacokinetic data
Protein binding <20%
Biological half-life 13 hours
Excretion Renal
CAS Registry Number 642-72-8 YesY
ATC code A01AD02 G02CC03 M01AX07 M02AA05
PubChem CID: 12555
ChemSpider 12036 YesY
UNII 4O21U048EF YesY
KEGG D07516 YesY
Chemical data
Formula C19H23N3O
Molecular mass 309.405 g/mol
 YesY (what is this?)  (verify)

Benzydamine (also known as Tantum Verde and branded in some countries as Difflam), available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.[1]

Medical use[edit]

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.

In some markets, the drug is supplied as an over-the-counter cream (Lonol in Mexico from Boehringer Ingelheim) used for topical treatment of musculoskeletal system disorders: sprains, strains, bursitis, tendinitis, synovitis, myalgia, periarthritis.

Antimicrobial activity[edit]

Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. [2][3]


There are no contraindications to the use of benzydamine except for known hypersensitivity.

Side effects[edit]

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur, as well as itching, a skin rash, skin swelling or redness, difficulty breathing and wheezing.


It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.[4]

Recreational use[edit]

Benzydamine has been used recreationally. In overdosages it acts a deliriant and CNS stimulant.[4] Such use, particularly among teenagers, has been reported in Poland,[4] Brazil[5][6] and Romania.


Benzydamine synthesis:[7] FR 1382855 ; Palazzo, U.S. Patent 3,318,905 (1964, 1967 both to Angelini Francesco)

An interesting alternative synthesis of this substance starts by sequential reaction of N-benzylaniline with phosgene, and then with sodium azide to product the corresponding carbonyl azide. On heating, nitrogen is evolved and a separatable mixture of nitrene insertion product and the desired ketoindazole # results. The latter reaction appears to be a Curtius rearrangement type product to produce an N-isocyanate #, which then cyclizes. Alkylation of the enol with sodium methoxide and 3-dimethylaminopropyl chloride gives benzydamine.

Alternatively, use of chloroacetamide in the alkylation step followed by acid hydrolysis produces bendazac instead.

See also[edit]


  1. ^ Turnbull, R. S. (1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal (Canadian Dental Association) 61 (2): 127–134. PMID 7600413. 
  2. ^ Fanaki NH, el-Nakeeb MA. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992 Dec;4(6):347-52. PMID 1287137
  3. ^ Fanaki NH, el-Nakeeb MA. Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against multifold resistant clinical isolates. Arzneimittelforschung. 1996 Mar;46(3):320-3. PMID 8901158
  4. ^ a b c Anand, J. S.; Lukasik–Glębocka, M.; Korolkiewicz, R. P. (2007). "Letter to the Editor: Recreational abuse with benzydamine hydrochloride (tantum rosa)". Clinical Toxicology 45 (2): 198–199. doi:10.1080/15563650600981210. PMID 17364645. 
  5. ^ Opaleye, E. S.; Noto, A. R.; Sanchez, Z. M.; Moura, Y. G.; Galduróz, J. C.; Carlini, E. A. (2009). "Recreational use of benzydamine as a hallucinogen among street youth in Brazil". Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 31 (3): 208–213. doi:10.1590/S1516-44462009000300005. PMID 19784487. 
  6. ^ Mota, D. M.; Costa, A. A.; Teixeira, C. D. S.; Bastos, A. A.; Dias, M. F. (2010). "Use abusive of benzydamine in Brazil: An overview in pharmacovigilance". Ciencia & saude coletiva (in Portuguese) 15 (3): 717–724. doi:10.1590/S1413-81232010000300014. PMID 20464184. 
  7. ^ a b Palazzo, G.; Corsi, G.; Baiocchi, L.; Silvestrini, B. (1966). "Synthesis and Pharmacological Properties of 1-Substituted 3-Dimethylaminoalkoxy-1H-indazoles". Journal of Medicinal Chemistry 9: 38. doi:10.1021/jm00319a009. 
  8. ^ L. Baiocchi, G. Corsi and G. Palazzo, Ann.Chim. (Roma), 55, 116 (1965).

External links[edit]