Bepridil

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Bepridil
Bepridil.svg
Systematic (IUPAC) name
N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline
Clinical data
Trade names Vascor
AHFS/Drugs.com monograph
MedlinePlus a699051
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral
Pharmacokinetic data
Bioavailability Well absorbed
Protein binding 99%
Metabolism Hepatic, CYP3A4-mediated
Biological half-life 42 hours
Excretion Renal
Identifiers
CAS Registry Number 64706-54-3 YesY
ATC code C08EA02
PubChem CID: 2351
IUPHAR/BPS 2337
DrugBank DB01244 YesY
ChemSpider 2261 YesY
UNII 755BO701MA YesY
ChEBI CHEBI:3061 YesY
ChEMBL CHEMBL1008 YesY
Chemical data
Formula C24H34N2O
Molecular mass 366.54 g/mol
 YesY (what is this?)  (verify)

Bepridil (trade name Vascor) is an amine calcium channel blocker once used to treat angina. It is no longer sold in the United States.

It is nonselective.[1]

It has been discussed as a possible option in the treatment of atrial fibrillation.[2]

It has been implicated in causing ventricular arrhythmia (Torsades de pointes).

Ebola Research[edit]

In June 2015 a research paper [3] was published revealing Vascor (Bepridil) resulted in a 100% survival rate for mice exposed to Ebola during an experiment searching for potential pharmaceutical Ebola treatments; indicating its potential use in future Ebola research and therapy.[4]

References[edit]

External links[edit]