The station is located on the elevated Berlin Stadtbahn line, which crosses central Berlin from east to west. The Stadtbahn carries local S-Bahn services on one pair of tracks, and longer distance services on another pair. Hackescher Markt station is served by S-Bahn lines S5, S7 and S75. Longer distance services pass the station without stopping.
The station opened in 1882 and was originally named Börse (stock exchange) and then Marx-Engels-Platz during the GDR era. In 1992 it received the name Hackescher Markt from the adjacent square. Following the demolition of the Lehrter Stadtbahnhof (architecturally similar and previously listed), with Bellevue it is now one of only two Stadtbahn stations preserved in their original condition.
As well as its rail connections, the station is also served by four tram lines, two of which run continuously. There are no bus services serving the station during the day, but is one of two main hubs in Berlin's night bus network. At night, six bus lines serve the station and there are guaranteed connections between many of these and the tram lines running at this time.