Bermekimab

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Bermekimab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetIL1A
Clinical data
Trade namesXilonix
SynonymsMABp1
Routes of
administration
intravenous
ATC code
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6464H10024N1736O2000S44
Molar mass145.5 g/mol g·mol−1

Bermekimab[1] (MABp1, trade name Xilonix) is a human monoclonal antibody of IgG1k isotype targeting Interleukin 1 alpha (IL1A).[2] As of March 2017, bermekimab is in phase III clinical trials as an immunotherapy for colorectal cancer[3] and as of September 2018 in phase II clinical trials for the treatment of atopic dermatitis.[4]

Bermekimab is being developed by XBiotech Inc.[5]

References[edit]

  1. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Bermekimab, American Medical Association.
  2. ^ Hong, David S; Hui, David; Bruera, Eduardo; Janku, Filip; Naing, Aung; Falchook, Gerald S; Piha-Paul, Sarina; Wheler, Jennifer J; Fu, Siqing; Tsimberidou, Apostolia M; Stecher, Michael; Mohanty, Prasant; Simard, John; Kurzrock, Razelle (May 2014). "MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study". The Lancet Oncology. 15 (6): 656-66. doi:10.1016/S1470-2045(14)70155-X. Retrieved 3 March 2017.
  3. ^ "A Phase III Study of Xilonix in Patients With Advanced Colorectal Cancer (XCITE)". ClinicalTrials.gov. U.S. National Institutes of Health. Retrieved 3 March 2017.
  4. ^ "A Phase II Study of Bermekimab (MABp1) in Patients With Moderate to Severe Atopic Dermatitis". ClinicalTrials.gov. U.S. National Institutes of Health. Retrieved 18 December 2018.
  5. ^ "Xilonix™ True Human™ monoclonal antibody by Xbiotech oncology". www.xbiotech.com. XBiotech. Retrieved 3 March 2017.