Best Brains, Inc. (first known as Hair Brain Productions) is an entertainment company based in Eden Prairie, Minnesota. It is best known for the creation and production of the comedy/sci-fi television program Mystery Science Theater 3000, aka MST3K (1988–1999). The company ceased producing the program when it was cancelled by The Sci-Fi Channel in 1999 and closed its studio. The company then functioned as the holder of the MST3K brand for negotiating home video releases of the show on Shout! Factory and its availability on streaming services like Hulu.
According to Joel Hodgson, the name "Best Brains" came from "...a phrase I found in a magic catalog. It was the old 'Vick Lawston' magic catalog. The copy read something like: 'from some of the Best Brains in the magic business!'"
On November 5, 2007, Jim Mallon and Paul Chaplin of Best Brains revived the MST3K brand by launching a new series of Flash-based animated shorts featuring the robots of Mystery Science Theater 3000 on the official website. The series was ended after several months due to cost issues.
On November 10, 2015, Shout! Factory announced it had purchased MST3K and its associated intellectual property from Best Brains for an undisclosed sum. On the same day, MST3K creator Joel Hodgson announced a crowdsourcing campaign to revive the program.