beta-Naphthoflavone

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beta-Naphthoflavone
Beta-Naphthoflavone.svg
Names
IUPAC name
3-phenyl-1H-benzo[f]chromen-1-one
Other names
5,6-Benzoflavone, BNF
Identifiers
3D model (Jmol)
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.025.417
Properties
C19H12O2
Molar mass 272.30 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

beta-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs).[1] β-Naphthoflavone is a putative chemopreventive agent.[2]

See also[edit]

References[edit]

  1. ^ Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L (2007). "Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture". Planta Med. 73 (8): 742–7. doi:10.1055/s-2007-981548. PMID 17599282. 
  2. ^ Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S (2005). "Modulation of multigene expression and proteome profiles by chemopreventive agents". Mutat Res. 591 (1–2): 212–23. doi:10.1016/j.mrfmmm.2005.03.032. PMID 16083920.