S,9 R,10 S,11 S,13 S,14 S,16 S,17 R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3 H-cyclopenta[ a]phenanthren-3-one
Trade names Celestone
US: C (Risk not ruled out)
Biological half-life 36-54 hours
Renal (in urine)
CAS Registry Number
A07 EA04 C05 AA05 D07 AC01 H02 AB01 R01 AD06 R03 BA04 S01 BA06 S02 BA07 S03 BA03
C 22 H 29 F O 5
Molecular mass 392.461
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Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.
It is on the
World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. [1 ]
Medical uses [ edit ]
Betamethasone is a
corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals, include the steroid as the valerate ester.
In a randomized controlled trial Betamethasone was shown to reduce some of the ataxia symptoms associated with
Ataxia Telangiectasia (A-T) by 28-31%. [2 ]
Alternative medical approach for large microcystic CCAMs – Betamethasone therapy
Betamethasone is also used prior to delivery of a
preterm baby to help prepare the lung for breathing.
Betamethasone is also used to treat
phimosis (tight foreskin) in uncircumcised boys. [3 ]
Side effects [ edit ]
Skin irritation, e.g. itching, burning, stinging.
Thinning of the skin.
Changes in skin pigmentation and coloration.
Stretch marks (striae).
Groupings of fine blood vessels becoming prominent under the skin (telangiectasia).
Excessive hair growth (
Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the
A cream with 0.05% betamethasone appears effective in treating
phimosis in boys, and often averts the need for circumcision. [4 ] [5 ] It has replaced circumcision as the preferred treatment method for some physicians in the [6 ] British National Health Service. [7 ] [8 ]
Betamethasone is also used to stimulate fetal lung maturation (
prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed . in utero
Betamethasone is available in a number of compound forms:
betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort in Pakistan and others), sodium phosphate (branded as Bentelan in Italy ) and [9 ] valerate (branded as Audavate, Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid for using in psoriatic skin conditions. In Mexico it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix.
See also [ edit ]
References [ edit ]
^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013 . Retrieved . 22 April 2014
^ Zannolli, R; Buoni, S; Betti, G; Salvucci, S; Plebani, A; Soresina, A; Pietrogrande, MC; Martino, S; Leuzzi, V; Finocchi, A; Micheli, R; Rossi, LN; Brusco, A; Misiani, F; Fois, A; Hayek, J; Kelly, C; Chessa, L (Sep 1, 2012). "A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia.". Movement disorders : official journal of the Movement Disorder Society 27 (10): 1312–6. doi: 10.1002/mds.25126. PMID 22927201.
^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi: 10.1542/peds.102.4.e43. PMID 9755280. A review of estimated costs and complications of 3 phimosis treatments.
^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi: 10.1046/j.1464-410x.2001.02033.x. PMID 11167650.
^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi: 10.1097/00005392-199909010-00078. PMID 10458396.
External links [ edit ]