Schmidt began her career at the age of seven with TSV 1880 Gera-Zwötzen. The club changed its name to 1. FC Gera 03 after a merger in 2003. During her entire youth career up to Under-15 level in the 2005–06 season, she played as the only girl on the team and only knew women's football from state selection squads and junior national teams.
In 2006, Schmidt moved to the reigning German club champions 1. FFC Turbine Potsdam while she attended the Friedrich Ludwig JahnPotsdam Sport School, which has an elite programme for girls' football. The school has very close links with the FFC Turbine Potsdam club. Schmidt soon became a regular starter for the team. She scored eight goals in her first Bundesliga season and won the Fritz Walter bronze medal as the third best female junior player of the year. At Potsdam, Schmidt won three Bundesliga titles in a row from 2009 to 2011. She also claimed the UEFA Women's Champions League in the 2009–10 season with the team, where she scored during the penalty shoot-out in the final. One year later, Potsdam again made it to the final, but lost against Olympique Lyonnais.