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IUPAC name
2-(Bis(2-hydroxyethyl)amino)acetic acid
Other names
N,N-Bis(2-hydroxyethyl)glycine; Diethylolglycine; Diethanol glycine; Dihydroxyethylglycine; BHG
150-25-4 N
Abbreviations DHEG
ChEBI CHEBI:39066 YesY
ChEMBL ChEMBL1231251 N
ChemSpider 8431 YesY
DrugBank DB03709 YesY
Jmol 3D model Interactive image
PubChem 8761
Molar mass 163.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Bicine is an organic compound used as a buffering agent. It is one of Good's buffers and has a pKa of 8.35 at 20 °C.[1] It is prepared by the reaction of glycine with ethylene oxide, followed by hydrolysis of the resultant lactone.[2]

Bicine is a contaminant in amine systems used for gas sweetening. It is formed by amine degradation in the presence of O2, SO2, H2S or Thiosulfate.[3]

See also[edit]


  1. ^ N,N-Bis(2-hydroxyethyl)glycine at ChEBI
  2. ^ The Merck Index (10th ed.). Rahway, NJ: Merck & Co. 1983. p. 453. ISBN 0-911910-27-1. 
  3. ^ Lawson, Gary (2003). "Amine Plant Corrosion Reduced by Removal of Bicine" (PDF). Gas Processors Association Annual Convention. Retrieved March 2016.  Check date values in: |access-date= (help)