Bifidobacterium animalis

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Bifidobacterium animalis
20101210 013757 BifidobacteriumAnimalis.jpg
Scientific classification
Kingdom: Bacteria
Division: Firmicutes
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: B. animalis
Binomial name
Bifidobacterium animalis
(Mitsuoka 1969)
Scardovi and Trovatelli 1974

B. a. animalis
B. a. lactis

Bifidobacterium animalis is a gram-positive, anaerobic, rod-shaped bacterium which can be found in the large intestines of most mammals, including humans.

Bifidobacterium animalis and Bifidobacterium lactis were previously described as two distinct species. Presently, both are considered B. animalis with the subspecies Bifidobacterium animalis subsp. animalis and Bifidobacterium animalis subsp. lactis.[1][2][3]

Both old names B. animalis and B. lactis are still used on product labels, as this species is frequently used as a probiotic. In most cases, which subspecies is used in the product is not clear.

Trade names[edit]

Several companies have attempted to trademark particular strains, and as a marketing technique, have invented scientific-sounding names for the strains.

Danone (Dannon) markets the subspecies strain DN 173 010 as Bifidus Digestivum (UK), Bifidus Regularis (US and Mexico), Bifidobacterium Lactis or B.L. Regularis (Canada), DanRegularis (Brazil), Bifidus Actiregularis (Argentina, Austria, Belgium, Bulgaria, Chile, Czech Republic, France, Germany, Greece, Hungary, Israel, Italy, Kazakhstan, Netherlands, Portugal, Romania, Russia, South Africa, Spain and the UK), and Bifidus Essensis in the Middle East (and formerly in Hungary, Bulgaria and The Netherlands) through Activia from Safi Danone KSA.[citation needed]

Chr. Hansen A/S [4] from Denmark has a similar claim on a strain of Bifidobacterium animalis subsp. lactis, marketed under the trademark BB-12.[5]

Lidl lists "Bifidobacterium BB-12" in its "Proviact" yogurt.

Bifidobacterium lactis Bl-04 and Bi-07 are strains from DuPont's Danisco FloraFIT range. They are used in many dietary probiotic supplements.

Therelac contains the strains "Bifidobacterium lactis BI-07" and "Bifidobacterium lactis BL-34" (also called BI-04) in its probiotic capsule.[6]

Bifidobacterium lactis HN019 is a strain from Fonterra licensed to DuPont, which markets it as HOWARU Bifido. It is sold in a variety of commercial probiotics, among them Tropicana Products Essentials Probiotics[7], Attune Wellness Bars[8] and NOW Foods Clinical GI Probiotic.[9] Fonterra has a yogurt that is sold in New Zealand called Symbio Probalance, where the strain is labelled as DR10.


Bifidobacterim animalis subspecies lactis BB-12 administered in combination with other probiotics has showed a small beneficial effect in a study of 32 patients with ulcerative colitis.[10]


B. animalis is present in many food products and dietary supplements. The probiotic is mostly found in dairy products.[11]

Health concerns[edit]

The manipulation of the gut flora is complex and may cause bacteria-host interactions.[12] Although probiotics, in general, are considered safe, there are concerns about their use in certain cases.[12][13] Some people, such as those with compromised immune systems, short bowel syndrome, central venous catheters, heart valve disease and premature infants, may be at higher risk for adverse events.[14] Rarely, consumption of probiotics may cause bacteremia, and sepsis, potentially fatal infections in children with lowered immune systems or who are already critically ill.[15]


  1. ^ Bifidobacterium
  2. ^ Masco, Liesbeth; Marco Ventura; Ralf Zink; Geert Huys; Jean Swings (July 2004). "Polyphasic taxonomic analysis of Bifidobacterium animalis and Bifidobacterium lactis reveals relatedness at the subspecies level: reclassification of Bifidobacterium animalis as Bifidobacterium animalis subsp. animalis subsp. nov. and Bifidobacterium lactis as Bifidobacterium animalis subsp. lactis subsp. nov.". Int J Syst Evol Microbiol. 54 (part 4): 1137–1143. doi:10.1099/ijs.0.03011-0. PMID 15280282. Retrieved 2007-07-14. 
  3. ^ Rapid Identification, Differentiation, and Proposed New Taxonomic Classification of Bifidobacterium lactis. Appl Environ Microbiol. 2002 December; 68(12): 6429–6434.
  4. ^
  5. ^
  6. ^
  7. ^
  8. ^
  9. ^
  10. ^ Ghouri YA, Richards DM, Rahimi EF, Krill JT, Jelinek KA, DuPont AW (Dec 9, 2014). "Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease". Clin Exp Gastroenterol (Review). 7: 473–87. doi:10.2147/CEG.S27530. PMC 4266241free to read. PMID 25525379. 
  11. ^ "American Society for MicrobiologyApplied and Environmental Microbiology." Strain-Specific Genotyping of Bifidobacterium Animalis Subsp. Lactis by Using Single-Nucleotide Polymorphisms, Insertions, and Deletions. N.p., n.d. Web. 03 June 2014.
  12. ^ a b Durchschein F, Petritsch W, Hammer HF (2016). "Diet therapy for inflammatory bowel diseases: The established and the new.". World J Gastroenterol (Review). 22 (7): 2179–94. doi:10.3748/wjg.v22.i7.2179. PMC 4734995free to read. PMID 26900283. 
  13. ^ Boyle RJ, Robins-Browne RM, Tang ML (2006). "Probiotic use in clinical practice: what are the risks?". Am J Clin Nutr (Review). 83 (6): 1256–64; quiz 1446–7. PMID 16762934. 
  14. ^ Doron S, Snydman DR (2015). "Risk and safety of probiotics.". Clin Infect Dis (Review). 60 Suppl 2: S129–34. doi:10.1093/cid/civ085. PMC 4490230free to read. PMID 25922398. 
  15. ^ Singhi SC, Kumar S (2016). "Probiotics in critically ill children.". F1000Res (Review). 5. doi:10.12688/f1000research.7630.1. PMC 4813632free to read. PMID 27081478. 

External links[edit]