Bifonazole

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Bifonazole
Bifonazole.svg
Clinical data
Trade namesCanespor, many others
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Topical
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.056.651 Edit this at Wikidata
Chemical and physical data
FormulaC22H18N2
Molar mass310.392 g/mol
3D model (JSmol)
ChiralityRacemic mixture
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Bifonazole (trade name Canespor among many others[1]) is an imidazole antifungal drug used in form of ointments.

There are also combinations with carbamide for the treatment of onychomycosis.

Adverse effects[edit]

The most common side effect is a burning sensation at the application site. Other reactions, such as itching, eczema or skin dryness, are rare.[2]

Pharmacology[edit]

Mechanism of action[edit]

Bifonazole has a dual mode of action. It inhibits fungal ergosterol biosynthesis at two points, via transformation of 24-methylendihydrolanosterol to desmethylsterol, together with inhibition of HMG-CoA. This enables fungicidal properties against dermatophytes and distinguishes bifonazole from other antifungal drugs.[2][3]

Pharmacokinetics[edit]

Six hours after application, bifonazole concentrations range from 1000 µg/cm³ in the stratum corneum to 5 µg/cm³ in the papillary dermis.[2]

References[edit]

  1. ^ International Drug Names: Bifonazole.
  2. ^ a b c Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Canesten Bifonazol-Creme.
  3. ^ Berg, D; Regel, E; Harenberg, H. E.; Plempel, M (1984). "Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole". Arzneimittel-Forschung. 34 (2): 139–46. PMID 6372801.