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Big Boss may refer to:
- Big Boss (Metal Gear), a central character from the Metal Gear video game series by Konami
- Venom Snake, Big Boss's body double from Metal Gear Solid V: The Phantom Pain
- Big Boss (musician), Czech metal singer
- Big Boss (C.O.P.S.), from the C.O.P.S. (Central Organization of Police Specialists) toyline by Hasbro
- The Big Boss, a 1941 crime drama film directed by Charles Barton
- The Big Boss, a 1971 Hong Kong martial arts-action film starring Bruce Lee
- The Big Boss (1921 film), German silent crime film
- Big Boss (film), a 1995 Telugu film directed by Vijaya Bapineedu
- Bigg Boss, an Indian reality TV show based on Big Brother
| disambiguation page lists articles associated with the title Big Boss.
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