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Big Trouble may refer to:
- Big Trouble (band), an American pop group from 1987 to 1988
- Big Trouble (Big Trouble album), 1988
- Big Trouble (Hazzard Hotrods album), 2000
- Big Trouble (Hollywood Monsters album), 2014
- Big Trouble (novel), a 1999 novel written by Dave Barry
- Big Trouble (2002 film), a 2002 American comedic film based on the novel
- Big Trouble (1986 film), a 1986 American comedy film directed by John Cassavetes
| disambiguation page lists articles associated with the title Big Trouble.
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