Bile duct hamartoma

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Micrograph of a bile duct hamartoma. Trichrome stain.

A bile duct hamartoma or biliary hamartoma, is a benign tumour-like malformation of the liver.

They are classically associated with polycystic liver disease, as may be seen in the context of polycystic kidney disease, and represent a malformation of the liver plate.[1]


The eponymous terms (von Meyenburg complex, Meyenburg complex) are named for Hanns von Meyenburg.[2][3]


At CT scans, bile duct hamartomas appear as small, well-defined hypo- or isoattenuating masses with little or no enhancement after contrast administration.[4] At MRI, they appear hypointense on T1-weighted images, iso- or slightly hyperintense on T2-weighted images, and hypointense after administration of gadolinium based contrast-agent.[4] On imaging, multiple hamartomas may look similar to metastases or microabscesses.

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  1. ^ Desmet, VJ (Jan 1998). "Ludwig symposium on biliary disorders--part I. Pathogenesis of ductal plate abnormalities.". Mayo Clin Proc. 73 (1): 80–9. PMID 9443684. doi:10.4065/73.1.80. 
  2. ^ synd/1693 at Who Named It?
  3. ^ H. von Meyenburg. Über die Zyztenleber. Beiträge zur pathologischen Anatomie und zur allgemeinen Pathologie, Jena, 1918, 64: 477-532.
  4. ^ a b Horton, KM; Bluemke, DA; Hruban, RH; Soyer, P; Fishman, EK (Mar–Apr 1999). "CT and MR imaging of benign hepatic and biliary tumors.". Radiographics : a review publication of the Radiological Society of North America, Inc. 19 (2): 431–51. PMID 10194789. doi:10.1148/radiographics.19.2.g99mr04431. 

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