Biliverdin reductase A

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biliverdin reductase A
Bilivra.jpg
Biliverdin reductase A dimer, Human
Identifiers
EC number1.3.1.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
BLVRA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBLVRA, BLVR, BVR, BVRA, biliverdin reductase A
External IDsMGI: 88170 HomoloGene: 572 GeneCards: BLVRA
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for BLVRA
Genomic location for BLVRA
Band7p13Start43,758,680 bp[1]
End43,807,342 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000712
NM_001253823

NM_026678

RefSeq (protein)

NP_000703
NP_001240752

NP_080954

Location (UCSC)Chr 7: 43.76 – 43.81 MbChr 2: 127.07 – 127.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.[5]

Function[edit]

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.[5]

Clinical significance[edit]

Mutations in this gene are associated with hyperbiliverdinemia.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106605 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001999 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b c "Entrez Gene: Biliverdin reductase A".

External links[edit]

  • Human BLVRA genome location and BLVRA gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Biliverdin reductase A

This article incorporates text from the United States National Library of Medicine, which is in the public domain.