Leeb began his musical career with industrial band Skinny Puppy in 1985 under the pseudonym Wilhelm Schroeder, contributing bass synth and occasional backing vocals to a few of their recordings and concerts. He left in mid 1986 and formed his own industrial project Front Line Assembly with Michael Balch, and later Rhys Fulber and Chris Peterson. Though Front Line Assembly has had consistent underground success, Leeb's most widely known efforts are through his side project, Delerium, which had a major hit in the late 1990s with "Silence".
Musical projects in which Bill Leeb has participated in include:
Leeb has been in a relationship with Canadian artist Carylann Loeppky for over 20 years. The couple have been married but are now divorced. Loeppky was part of the tour personnel on Front Line Assembly tours "designing and selling merchandise and put together a visual presentation for the live performance." She also created the artwork for albums of Front Line Assembly and Delerium.