Headquarters in Mainz
|Type||Public (Societas Europaea)|
(English depository receipts)
Number of locations
|Revenue||€121.5 million (2019)|
|−181,518,000 euro (2019)|
|−179,172,000 euro (2019)|
|Total assets||€797.7 million (2019)|
|Total equity||€232.3 million (2019)|
Number of employees
|Footnotes / references|
BioNTech SE (short for Biopharmaceutical New Technologies) is a German biotechnology company based in Mainz that develops and manufactures active immunotherapies for patient-specific approaches to the treatment of diseases. It develops pharmaceutical candidates based on messenger ribonucleic acid (mRNA) for use as individualized cancer immunotherapies, as vaccines against infectious diseases and as protein replacement therapies for rare diseases, and also engineered cell therapy, novel antibodies and small molecule immunomodulators as treatment options for cancer.
The company has developed an mRNA-based human therapeutic for intravenous administration to bring individualized mRNA-based cancer immunotherapy to clinical trials and to establish its own manufacturing process.
In 2020 BioNTech developed, in conjunction with Pfizer, the RNA vaccine BNT162b2 for preventing COVID-19 infections, which offers a 95% efficacy. On 2 December 2020, temporary HMR authorization was granted by the United Kingdom government for BNT162b2 vaccinations within the UK. It was the first mRNA vaccine ever authorized. Some days later the vaccine got also an emergency approval in the United States, Canada, and Switzerland. On 21 December 2020, the European Commission approved BioNTech/Pfizer's coronavirus vaccine in accordance with the positive recommendation of the European Medicines Agency (EMA).
BioNTech was founded in 2008 based on research by Uğur Şahin, Özlem Türeci, and Christoph Huber, with a seed investment of €150 million. The company's activities focus on the development and production of technologies and drugs for individualized cancer immunotherapy. Andreas and Thomas Strüngmann, Michael Motschmann, and Helmut Jeggle were cofounders. In 2009, the acquisition of EUFETS and JPT Peptide Technologies took place. In 2013, Katalin Karikó joined BioNTech as a senior vice president.
Between 2014 and 2018, many research results on mRNA mechanisms were published by BioNTech. Collaborations and commercialization programs were concluded with various companies and scientific institutions starting in 2015. During this period, BioNTech filed several patent applications and developed a multi-layered strategy to protect its intellectual property in the various technology platforms and their application in the treatment of cancer and other serious diseases.
Nasdaq IPO (2019)
Since 10 October 2019, BioNTech, with its newly founded North American headquarter in Cambridge, Massachusetts, has been publicly traded as American Depository Shares (ADS) on the Nasdaq Global Select Market under the ticker symbol, BNTX. BioNTech was able to generate total gross proceeds of 150 million dollars from the IPO.
BioNTech's founding place and global headquarter is Mainz, Germany. The company runs multiple sites in the city.
Further research locations are in San Diego and Cambridge (Mass.) with also serves as the North American headquarters.
Additionally the company owns GMP-certfified production facilities in Idar-Oberstein, Martinsried, Neuried and Berlin. In November 2020, the company acquired facilities from Novartis in Marburg to ramp up its vaccine production.
Investments and financing
In June 2020, BioNTech received €250 million from Temasek Holdings (Singapore) via the purchase of ordinary shares and 4 years convertible notes, but also from other investors through a private placement of mandatory convertible bonds. It also received €100 million from the European Investment Bank in debt financing.
The project to develop a novel mRNA technology for a COVID-19 vaccine was called "Project Lightspeed", which started in mid-January 2020 just days after the SARS-Cov-2 genetic sequence was first made public. The company is working to develop the Pfizer–BioNTech COVID-19 vaccine with Pfizer and Fosun.
The production of the vaccine was followed by clinical trials, the success of which was a prerequisite for the commencement of marketing. On November 9, 2020, BioNTech and Pfizer announced that 43,500 people in 6 countries have got a test vaccine against COVID-19 and the clinical trials had more than 90 percent effectiveness. On the basis of successful testing, they asked for the right to distribute vaccines in the United States, as well as in the European Union, the United Kingdom and Japan.
BioNTech and Pfizer signed contracts to supply 300 million doses of a SARS-CoV-2 vaccine for the European Union, 120 million doses for Japan, 100 million doses for the United States, and 40 million doses for the United Kingdom, if proven effective, safe, and licensed.
On 10 November 2020 following positive interim analysis of a Phase III clinical trial in the United States, the BioNTech-Pfizer partners applied for an EUA with the FDA, which is scheduled to review the application by mid-December. The FDA released a document explaining that an EUA is "a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic.". In November, Pfizer submitted an EUA application in Canada.
On 2 December 2020, the United Kingdom granted conditional temporary authorisation (under Regulation 174 of the Human Medicines Regulations 2012) for BNT162b2, becoming the first country to approve an mRNA vaccine and the first Western country to approve a COVID-19 vaccine for national use. BNT162b2 was under evaluation during December for emergency use authorization (EUA) status in several other countries.
The European Medicines Agency (EMA) authorized one-year conditional use of the BioNTech/Pfizer vaccine in the European Union on 21 December 2020. Emer Cooke, director of the EMA, stated that the benefits of the vaccine far outweigh the potential risks. The price of a dose of BioNTech/Pfizer vaccine is €12. (For comparison this costs more than four of its future five competitors: Oxford/AstraZeneca: €1.78; Johnson & Johnson: €8.50; Sanofi/GSK: €7.56; CureVac: €10; but Moderna's vaccine is more expensive, costing €18.) Under the agreement, the vaccine-producing pair, BioNTech and Pfizer are subject to a tightened legal obligation to bring all the experience they have gained to the EMA for review.
Following the authorization mass vaccination against coronavirus was started for the first time in Hungary and Slovakia in the European Union on 26 December 2020.
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