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Biotene (typeset as biotène) is a dental hygiene product originally manufactured by Laclede Inc. but now marketed by GlaxoSmithKline. It comes in a number of forms, including toothpaste, mouthwash and gel.



The main active ingredient in its toothpastes is sodium monofluorophosphate, and prior to the GlaxoSmithKline acquisition it also contained enzymes including glucose oxidase, lactoferrin, lactoperoxidase and lysozyme.


The PBF ORAL RINSE (plaque biofilm) product contains the enzymes mutanase, dextranase, lysozyme, lactoperoxidase, and glucose oxidase.[1]


Patients with xerostomia (dry mouth) may use Biotène to reduce the rate of recurrence of dental plaque. However, Biotene by itself does not significantly reduce the count of Streptococcus mutans which is the primary initiator of the formation of dental plaque.[2]


  1. ^ "Biotene website". 
  2. ^ Lehane RJ, Murray PA, Deasy MJ (1997). "Effect of an enzymatic rinse on salivary levels of Streptococcus mutans and lactobacilli in periodontally treated patients". Periodontal Clinical Investigations. 19 (2): 17–21. PMID 9495936. 

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