Bis-tris methane

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Bis-tris methane
Skeletal formula of bis-tris methane
IUPAC name
Other names
  • Bis-(2-hydroxy-ethyl)-amino-tris(hydroxymethyl)-methane
  • 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol
  • 2,2-Bis(hydroxymethyl)-2,2,2-nitrilotriethanol
3D model (Jmol)
ECHA InfoCard 100.027.489
EC Number 230-237-7
MeSH Bistris
RTECS number TY2900000
Molar mass 209.24 g·mol−1
Appearance White crystals
Odor Odourless
Melting point 102 to 103 °C (216 to 217 °F; 375 to 376 K)
209.2 g L−1 (at 20 °C)
Acidity (pKa) 6.46
Basicity (pKb) 7.54
UV-vismax) 280 nm
Absorbance 0.15
GHS pictograms The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word WARNING
H315, H319, H335
P261, P305+351+338
Irritant Xi
R-phrases R36/37/38
S-phrases S26, S36
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Related compounds
Related alkanols
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Bis-tris methane is a buffering agent used in biochemistry. Bis-tris methane is an organic tertiary amine with labile protons having a pKa of 6.46 at 25 °C. It is an effective buffer between the pH 5.8 and 7.3.

See also[edit]


  1. ^ "Bistris - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 23 June 2005. Identification. Retrieved 9 April 2012.