Bismuth subgallate

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Bismuth subgallate
Skeletal formula of bismuth subgallate
Ball-and-stick model of the bismuth subgallate molecule
Systematic (IUPAC) name
2,7-dihydroxy-1,3,2-benzodioxabismole-5-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Legal status
Identifiers
CAS Number 99-26-3 N
ATC code A07BB (WHO)
PubChem CID 16682999
ChemSpider 10607905 YesY
UNII YIW503MI7V N
ChEBI CHEBI:31292 YesY
Chemical data
Formula C7H5BiO6
Molar mass 394.091 g·mol−1
Physical data
Density 1.1 g/cm3
 NYesY (what is this?)  (verify)

Bismuth subgallate, with a chemical formula C7H5BiO6, is commonly used to treat malodor by deodorizing flatulence and stools. In the United States it is the active ingredient in Devrom (internal deodorant), an over-the-counter FDA-approved medicine. Also, it has been used to treat Helicobacter pylori infection and is used in wound therapy. As an internal deodorant, it is commonly used by individuals who have had gastrointestinal stoma surgery, bariatric surgery, fecal incontinence, and irritable bowel syndrome.[1]

Also, a double blind study in 1974 reported its effectiveness as a flatulence/stool deodorant in ileostomy patients.[2]

Adverse effects[edit]

It can cause darkening of the tongue and stools, which is temporary.[3]

In 1974, a reversible encephalopathy was noted and examined in four colon cancer patients taking bismuth subgallate after abdominoperineal resection.[4]

Bismuth subgallate is contraindicated in case of hypersensitivity to the substance, and should be used with caution in people with liver disease or kidney disease.[3] It is grouped in pregnancy category C[3] (risk not ruled out: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks). During lactation, very little bismuth subgallate passes over to the child.[3]

See also[edit]

External links[edit]

  • American Cancer Society: Ileostomy Guide [1]
  • Cleveland Clinic-Having an Ileostomy– A Primer for New Ostomates [2]
  • The Ostomy Files:The Issue of Oral Medications and a Fecal Ostomy [3]
  • Devrom website [4]
  • Gulp: Adventures on the Alimentary Canal by Mary Roach [6]

References[edit]

  1. ^ Gorbach S. L. (1990). "Bismuth therapy in gastrointestinal diseases". Gastroenterology. 99 (3): 863–75. PMID 2199292. 
  2. ^ Sparberg M. (1974). "Correspondence: Bismuth subgallate as an effective means for the control of ileostomy odor: a double blind study". Gastroenterology. 66 (3): 476. PMID 4813513. 
  3. ^ a b c d "Bismuth subgallate (OTC) Devrom". Medscape. Retrieved 2015-12-02. 
  4. ^ Burns R.; Thomas D. W.; Barron V. J. (1974). "Reversible encephalopathy possibly associated with bismuth subgallate ingestion". British Medical Journal. 9 (1): 220–3. PMC 1633100free to read. PMID 4818163.