In 2005, American singer-songwriter Ben Folds released a cover version of "Bitches Ain't Shit", which reached number 71 on the US Billboard Hot 100. Folds commonly includes the song in his live performances, one such time being on October 24, 2006, at his MySpace webcast gig. During his June 14, 2008 performance at the Bonnaroo Music and Arts Festival, Folds claimed he was retiring the song because people on the streets would call him, "...that 'Bitch' guy," in front of his kids. Two weeks later, however, he included the song in his set at the Glastonbury Festival. He claimed a friend had requested it to be played at her wedding. There are also a few a cappella versions of Ben Folds' cover available on YouTube. In 2010, Folds took the song out of retirement and has played it as part of the encore at a concert in Indianapolis, Indiana, and Detroit, Michigan, as well as other concerts.
In 2010, Louisiana-based rapper Lil Boosie, recorded a remake titled "Niggas Ain't Shit", released on his mixtape, Gone Til' December.
In 2011, Los Angeles-based rapper YG, released a song titled "Bitches Ain't Shit", featuring Tyga and Nipsey Hussle. The song, which heavily samples Dr. Dre's version, was featured on YG's mixtape Just Re Up'd and reached number 90 the US Billboard Hot 100.
In July 2013, YouTube personality George "Joji Miller, also known as "TVFilthyFrank" created a ukulele cover of the song under his "Pink Guy" persona. The song was later released on his album Pink Guy in 2014.