Bitot's spots

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Bitot's spots
Classification and external resources
Specialty endocrinology
ICD-10 E50.1
ICD-9-CM 264.1
Typical location of Bitot's spots

Bitot's spots are the buildup of keratin located superficially in the conjunctiva, which are oval, triangular or irregular in shape. These spots are a sign of vitamin A deficiency and are associated with conjunctival xerosis. In 1863, Pierre Bitot (1822-1888), a French physician, first described these spots.[1]

In ancient Egypt, this was treated with animal liver, which is where vitamin A is stored.[2]


  1. Vitamin A
  2. Beta carotene


  1. ^ Shukla, M; Behari, K (Jul 1979). "Congenital Bitot spots.". Indian Journal of Ophthalmology. 27 (2): 63–4. PMID 541036. 
  2. ^ Numitor, Gerd (February 2012). Bitot's Spots. Flu Press. ISBN 978-620-0-57824-2. 

External links[edit]